ArticleJournal of dental research2018
Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.
Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Efficacy of fosaprepitant combined with tropisetron plus dexamethasone in preventing nausea and emesis during fractionated radiotherapy with weekly cisplatin chemotherapy: interim analysis of a randomized, prospective, clinical trial using competing risk analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Trial
- Acute radiation-induced changes in the submandibular salivary gland and possible radioprotective role of silver nanoparticles: a histological, immunohistochemical, and ultrastructural study.Anatomy & cell biology · 2026Article
- Laminarin attenuates irradiation-induced salivary gland hypofunction in mice: association with enhanced Nrf2-associated antioxidant responses.Odontology · 2026Article
- A γ-radiation-responsive diselenide-core micelle for on-demand delivery of cannabidiol in the mitigation of acute radiation injury.Materials today. Bio · 2026Article
- Salivary gland tissue chip screening identifies candidate radioprotective drugs.Communications medicine · 2025Article
- Melatonin may be an alternative to amifostine in salivary gland protection in irradiated rats.BMC oral health · 2025Article
- Article
- Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments.Cancers · 2025Review
- Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling.bioRxiv : the preprint server for biology · 2025Article
- Article
- Current basic and preclinical research for treatment of radiation therapy-induced hyposalivation.JADA foundational science · 2025Article
- A single dose of radiation elicits comparable acute salivary gland injury to fractionated radiation.Disease models & mechanisms · 2024Article
- Fibrin hydrogels fortified with FGF-7/10 and laminin-1 peptides promote regeneration of irradiated salivary glands.Acta biomaterialia · 2023Article
- Localized Drug Delivery Systems: An Update on Treatment Options for Head and Neck Squamous Cell Carcinomas.Pharmaceutics · 2023Review
- Short-term and bystander effects of radiation on murine submandibular glands.Disease models & mechanisms · 2022Article
- The impact of head and neck radiotherapy on salivary flow and quality of life: Results of the ORARAD study.Oral oncology · 2022Article
- Efficacy of corticosteroid ductal irrigation in acute salivary gland inflammation induced in a rat model.Imaging science in dentistry · 2022Article
- Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review.Journal of oncology · 2022Review
- Development of a functional salivary gland tissue chip with potential for high-content drug screening.Communications biology · 2021Article
- Laminin-1 Peptides Conjugated to Fibrin Hydrogels Promote Salivary Gland Regeneration in Irradiated Mouse Submandibular Glands.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
- Erratum issuedCorrigendum.2018
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Radiotherapy for head and neck cancers commonly causes damage to salivary gland tissue, resulting in xerostomia (dry mouth) and numerous adverse medical and quality-of-life issues. Amifostine is the only Food and Drug Administration-approved radioprotective drug used clinically to prevent xerostomia. However, systemic administration of amifostine is limited by severe side effects, including rapid decrease in blood pressure (hypotension), nausea, and a narrow therapeutic window. In this study, we demonstrate that retroductal delivery of amifostine and its active metabolite, WR-1065, to murine submandibular glands prior to a single radiation dose of 15 Gy maintained gland function and significantly increased acinar cell survival. Furthermore, in vivo stimulated saliva secretion was maintained in retrograde-treated groups at levels significantly higher than irradiated-only and systemically treated groups. In contrast to intravenous injections, retroductal delivery of WR-1065 or amifostine significantly attenuated hypotension. We conclude that localized delivery to salivary glands markedly improves radioprotection at the cellular level, as well as mitigates the adverse side effects associated with systemic administration. These results support the further development of a localized delivery system that would be compatible with the fractionated dose regimen used clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.