Evidence map›Paper›PMID 29634313›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2018

NAD

Lane C Porter, Michael P Franczyk, Terri Pietka, Shintaro Yamaguchi, Jonathan B Lin, Yo Sasaki, Eric Verdin, Rajendra S Apte, Jun Yoshino

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Emerging Roles of SIRT3 in Cardiac Metabolism.Frontiers in cardiovascular medicine · 2022
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lane C PorterCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Michael P FranczykCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Terri PietkaCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Shintaro YamaguchiCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Jonathan B LinDepartment of Ophthalmology, Washington University School of Medicine , St. Louis, Missouri.
Yo SasakiDepartment of Genetics, Washington University School of Medicine , St. Louis, Missouri.
Eric VerdinGladstone Institutes, University of California San Francisco , San Francisco, California.
Rajendra S ApteCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Jun YoshinoCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.
Washington University in St. Louis · USUniversity of California, San Francisco · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
THERMOGENESIS AND EXERCISE IN LEAN, OBESE, AND DIABETICR01DK037948 · NIDDK · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI KLEIN, SAMUEL · 1987 to 2012
$4.6M
THE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYER01EY019287 · NEI · WASHINGTON UNIVERSITY · PI APTE, RAJENDRA S · 2010 to 2021
$3.9M
REGULATION OF SYSTEMIC GLUCOSE AND LIPID HOMEOSTASIS BY ADIPOCYTE NAD BIOSYNTHESISR01DK104995 · NIDDK · WASHINGTON UNIVERSITY · PI KLEIN, SAMUEL · 2016 to 2024
$3.5M
NCATS NIH HHS TL1 TR002344NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NEI NIH HHS P30 EY002687NEI NIH HHS R01 EY019287NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P60 DK020579NIDDK NIH HHS R01 DK037948NIDDK NIH HHS R01 DK104995
6 · The paper itself

Abstract

Mitochondrial dysfunction in adipose tissue is involved in the pathophysiology of obesity-induced systemic metabolic complications, such as type 2 diabetes, insulin resistance, and dyslipidemia. However, the mechanisms responsible for obesity-induced adipose tissue mitochondrial dysfunction are not clear. The aim of present study was to test the hypothesis that nicotinamide adenine dinucleotide (NAD

Indexed as

AdipocytesAdipose TissueAnimalsDiet, High-FatEnergy MetabolismMiceMice, KnockoutMice, ObeseMitochondriaSirtuin 3Sirt3 protein, mouseSirtuin 3adipocyteadipose tissueglucose metabolismmitochondriaNAD+obesitySIRT3

Identifiers

PMID29634313
PMCPMC6230701
OpenAlexW2797455014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.