Evidence map›Paper›PMID 29634254›Full record

ArticleBioconjugate chemistry2018

Creation of Linear Carbon Dot Array with Improved Optical Properties through Controlled Covalent Conjugation with DNA.

Sonam Kumari, Apurv Solanki, Saptarshi Mandal, Deepa Subramanyam, Prolay Das

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sonam KumariDepartment of Chemistry , IIT Patna, Bihta , Patna 801103 , India.
Apurv SolankiNational Centre for Cell Science , Pune 411007 , Maharashtra , India.
Saptarshi MandalDepartment of Chemistry , IIT Patna, Bihta , Patna 801103 , India.
Deepa SubramanyamNational Centre for Cell Science , Pune 411007 , Maharashtra , India.ORCID 0000-0002-1650-5690
Prolay DasDepartment of Chemistry , IIT Patna, Bihta , Patna 801103 , India.ORCID 0000-0002-2774-8479

Funding

DBT-Wellcome Trust India Alliance IA/I/12/1/500507
6 · The paper itself

Abstract

Controlled conjugation of fluorescent carbon dots (CDs) with DNA and subsequent fabrication of the CDs into an array through hybridization mediated self-assembly in the solution phase is reported. Covalent conjugation of CD with DNA and the subsequent array formation change the mobility of the CD-DNA array in gel electrophoresis and HPLC significantly. Interspatial distance in the CD-DNA array is tuned by the DNA sequence length and maintained at ∼8 ± 0.3 nm as revealed by electron microscopy studies. An increase in fluorescence lifetime by ∼2 ns was observed for the CD-DNA array compared to a solitary CD, vis-á-vis better imaging prospects of HEK293 cells by the former. Thus, the array displays improved fluorescence and unhindered cell penetration.

Indexed as

Oligonucleotide Array Sequence AnalysisOptical ImagingCarbonDNAFluorescenceFluorescent DyesHEK293 CellsHumansNucleic Acid HybridizationQuantum DotsCarbonDNAFluorescent Dyes

Identifiers

PMID29634254
PMCPMC7116061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.