ArticleJournal of biophotonics2018
Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues.
Article in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Double Stokes polarimetry of birefringent structures.Biomedical optics express · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- High-Speed Full-Color Polarized Light Imaging of Collagen Using a Polarization Camera.Bioengineering (Basel, Switzerland) · 2025Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.Nature methods · 2024Article
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell.Experimental eye research · 2023Article
- Anterior Scleral Thickness Profile in Keratoconus.Life (Basel, Switzerland) · 2023Article
- Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression.Nature biomedical engineering · 2023Article
- A direct fiber approach to model sclera collagen architecture and biomechanics.Experimental eye research · 2023Article
- Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles.Journal of biomechanical engineering · 2023Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.bioRxiv : the preprint server for biology · 2023Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Lamina cribrosa vessel and collagen beam networks are distinct.Experimental eye research · 2022Article
- Single-Shot Quantitative Polarization Imaging of Complex Birefringent Structure Dynamics.ACS photonics · 2021Article
- Picrosirius-Polarization Method for Collagen Fiber Detection in Tendons: A Mini-Review.Orthopaedic surgery · 2021Review
- Instant polarized light microscopy for imaging collagen microarchitecture and dynamics.Journal of biophotonics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Collagen fibers play a central role in normal eye mechanics and pathology. In ocular tissues, collagen fibers exhibit a complex 3-dimensional (3D) fiber orientation, with both in-plane (IP) and out-of-plane (OP) orientations. Imaging techniques traditionally applied to the study of ocular tissues only quantify IP fiber orientation, providing little information on OP fiber orientation. Accurate description of the complex 3D fiber microstructures of the eye requires quantifying full 3D fiber orientation. Herein, we present 3dPLM, a technique based on polarized light microscopy developed to quantify both IP and OP collagen fiber orientations of ocular tissues. The performance of 3dPLM was examined by simulation and experimental verification and validation. The experiments demonstrated an excellent agreement between extracted and true 3D fiber orientation. Both IP and OP fiber orientations can be extracted from the sclera and the cornea, providing previously unavailable quantitative 3D measures and insight into the tissue microarchitecture. Together, the results demonstrate that 3dPLM is a powerful imaging technique for the analysis of ocular tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.