Evidence map›Paper›PMID 29633076›Full record

ArticleArchives of virology2018

Functional growth inhibition of influenza A and B viruses by liquid and powder components of leaves from the subtropical plant Melia azedarach L.

Kuniaki Nerome, Kazufumi Shimizu, Shiori Zukeran, Yasuhiro Igarashi, Kazumichi Kuroda, Shigeo Sugita, Toshikatsu Shibata, Yasuhiko Ito, Reiko Nerome

Open access · hybridAbstract read
In one paragraph

Article in Archives of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Antiviral activity of Azadirachta indica A. Juss and Melia azedarach extracts during the replication cycle of small ruminant lentiviruses.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. In vivo evaluation of the antiretroviral activity of Melia azedarach against small ruminant lentiviruses in goat colostrum and milk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kuniaki NeromeThe Institute of Biological Resources, 893-2, Nakayama, Nago-shi, Okinawa, 905-0004, Japan. rnerome_ibr@train.ocn.ne.jp.
Kazufumi ShimizuDivision of Microbiology, Nihon University School of Medicine, 30-1, Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Shiori ZukeranThe Institute of Biological Resources, 893-2, Nakayama, Nago-shi, Okinawa, 905-0004, Japan.
Yasuhiro IgarashiBiotechnology Research Center and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu-shi, Toyama, 939-0398, Japan.
Kazumichi KurodaDivision of Microbiology, Nihon University School of Medicine, 30-1, Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Shigeo SugitaEquine Research Institute, Japan Racing Association, 1400-4, Shiba, Shimotsuke-shi, Tochigi, 329-0412, Japan.
Toshikatsu ShibataDivision of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1, Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Yasuhiko ItoDepartment of Biomedical Sciences (Graduate School), College of Life and Health Sciences, Chubu University, 1200, Matsumoto-cho, Kasugai, Aichi, 487-6501, Japan.
Reiko NeromeThe Institute of Biological Resources, 893-2, Nakayama, Nago-shi, Okinawa, 905-0004, Japan.
Nihon University · JPChubu University · JPJapan Racing Association · JPToyama Prefectural University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the anti-influenza-virus effects of Melia components and discuss the utility of these components. The effects of leaf components of Melia azedarach L. on viruses were examined, and plaque inhibition tests were performed. The in vivo efficacy of M. azedarach L. was tested in a mouse model. Leaf components of Melia azedarach L. markedly inhibited the growth of various influenza viruses. In an initial screening, multiplication and haemagglutination (HA) activities of H1N1, H3N2, H5, and B influenza viruses were inactivated by the liquid extract of leaves of M. azedarach L. (MLE). Furthermore, plaque inhibition titres of H1N1, H3N2, and B influenza viruses treated with MLE ranged from 10

Indexed as

AnimalsAntiviral AgentsChick EmbryoChickensFemaleInfluenza A virusInfluenza B virusInfluenza in BirdsMelia azedarachMicePlant ExtractsPlant LeavesPoultry DiseasesAntiviral AgentsPlant Extracts

Identifiers

PMID29633076
PMCPMC6096724
OpenAlexW2798036976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.