Evidence map›Paper›PMID 29633056›Full record

ArticleIntensive care medicine experimental2018

Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis.

Gustavo A Cortes-Puentes, Kenneth E Gard, Alexander B Adams, David J Dries, Michael Quintel, Richard A Oeckler, Luciano Gattinoni, John J Marini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Gustavo A Cortes-PuentesDepartment of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. CortesPuentes.Gustavo@mayo.edu.
Kenneth E GardDepartment of Pulmonary and Critical Care Research, Regions Hospital, Office E3844, 640 Jackson Street, St. Paul, MN, 55101, USA.
Alexander B AdamsDepartment of Pulmonary and Critical Care Research, Regions Hospital, Office E3844, 640 Jackson Street, St. Paul, MN, 55101, USA.
David J DriesDepartment of Surgery, University of Minnesota, Regions Hospital, Office E3844, 640 Jackson Street, St. Paul, MN, 55101, USA.
Michael QuintelDepartment of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Richard A OecklerDepartment of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Luciano GattinoniDepartment of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
John J MariniDepartment of Pulmonary and Critical Care Medicine, University of Minnesota, Regions Hospital, MS11203B, 640 Jackson Street, St. Paul, MN, 55101, USA.
Regions Hospital · USUniversity of Göttingen · DEMayo Clinic · USMayo Clinic in Florida · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBody positioning affects the configuration and dynamic properties of the chest wall and therefore may influence decisions made to increase or decrease ventilating pressures and tidal volume. We hypothesized that unlike global functional residual capacity (FRC), component sector gas volumes and their corresponding regional tidal expansions would vary markedly in the setting of unilateral pleural effusion (PLEF), owing to shifting distributions of aeration and collapse as posture changed.

methodsSix deeply anesthetized swine underwent tracheostomy, thoracostomy, and experimental PLEF with 10 mL/kg of radiopaque isotonic fluid randomly instilled into either pleural space. Animals were ventilated at V

resultsNo significant differences in total FRC were observed among the horizontal positions, either at baseline (p = 0.9037) or with PLEF (p = 0.58). However, component sector total gas volumes in each phase of the tidal cycle were different within all studied positions with and without PLEF (p = < .01). Compared to other positions, prone and lateral positions with non-dependent PLEF had more homogenous V

conclusionsChanges in body position in the setting of effusion-caused chest asymmetry markedly affected the internal distributions of gas volume, collapse, ventilation, and tidal recruitment, even though global FRC measurements provided little indication of these potentially important positional changes.

Indexed as

Analysis of aerationBody positionChest wall asymmetryFunctional residual capacityPleural effusionProneQuantitative computed tomographyTidal recruitment

Identifiers

PMID29633056
PMCPMC5891440
OpenAlexW2796973110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.