Evidence map›Paper›PMID 29633002›Full record

ArticleEuropean radiology2018

Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using a radiomic approach.

Zhang Shi, Chengcheng Zhu, Andrew J Degnan, Xia Tian, Jing Li, Luguang Chen, Xuefeng Zhang, Wenjia Peng, Chao Chen, Jianping Lu and 3 more

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  18. A radiomic model based on 7T intracranial vessel wall imaging for identification of culprit middle cerebral artery plaque associated with subcortical infarctions.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Zhang ShiDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Chengcheng ZhuDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
Andrew J DegnanDepartment of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xia TianDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Jing LiDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Luguang ChenDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Xuefeng ZhangDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Wenjia PengDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Chao ChenDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Jianping LuDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Tao JiangDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
David SalonerDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
Qi LiuDepartment of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. liuqimd@126.com.ORCID http://orcid.org/0000-0001-7739-7497
Second Military Medical University · CNChildren's Hospital of Philadelphia · US

Funding

Characterization of intracranial vessel wall morphology and inflammation using 3D high resolution MRIK99HL136883 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHU, CHENGCHENG · 2017 to 2018
$181k
NHLBI NIH HHS K99 HL136883
6 · The paper itself

Abstract

objectivesTo evaluate a quantitative radiomic approach based on high-resolution magnetic resonance imaging (HR-MRI) to differentiate acute/sub-acute symptomatic basilar artery plaque from asymptomatic plaque.

methodsNinety-six patients with basilar artery stenosis underwent HR-MRI between January 2014 and December 2016. Patients were scanned with T1- and T2-weighted imaging, as well as T1 imaging following gadolinium-contrast injection (CE-T1). The stenosis value, plaque area/burden, lumen area, minimal luminal area (MLA), intraplaque haemorrhage (IPH), contrast enhancement ratio and 94 quantitative radiomic features were extracted and compared between acute/sub-acute and asymptomatic patients. Multi-variate logistic analysis and a random forest model were used to evaluate the diagnostic performance.

resultsIPH, MLA and enhancement ratio were independently associated with acute/subacute symptoms. Radiomic features in T1 and CE-T1 images were associated with acute/subacute symptoms, but the features from T2 images were not. The combined IPH, MLA and enhancement ratio had an area under the curve (AUC) of 0.833 for identifying acute/sub-acute symptomatic plaques, and the combined T1 and CE-T1 radiomic approach had a significantly higher AUC of 0.936 (p = 0.01). Combining all features achieved an AUC of 0.974 and accuracy of 90.5%.

conclusionsRadiomic analysis of plaque texture on HR-MRI accurately distinguished between acutely symptomatic and asymptomatic basilar plaques. KEY POINTS: • High-resolution magnetic resonance imaging can assess basilar artery atherosclerotic plaque. • Radiomic features in T1 and CE-T1 images are associated with acute symptoms. • Radiomic analysis can accurately distinguish between acute symptomatic and asymptomatic plaque. • The highest accuracy may be achieved by combining radiomic and conventional features.

Indexed as

AgedBasilar ArteryContrast MediaFemaleGadoliniumHumansIntracranial ArteriosclerosisMagnetic Resonance ImagingMaleMiddle AgedPlaque, AtheroscleroticContrast MediaGadoliniumAtherosclerotic plaquesBasilar arteryIntracranial arteriosclerosisMagnetic resonance imagingStroke

Identifiers

PMID29633002
PMCPMC6081255
OpenAlexW2797200581

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.