ArticleFrontiers in bioengineering and biotechnology2018
Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds-Present and Future Strain Construction Strategies.
Article in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- A non-classical biosynthetic route enables tocopherol synthesis in bacteria.Nature metabolism · 2026Article
- Advances in Betalain Biosynthesis and Metabolic Engineering for Sustainable Natural Pigment Production.Biotech (Basel (Switzerland)) · 2026Review
- Shikimate pathway disruption in yeast induces metabolite self-assembly into toxic aggregates.The FEBS journal · 2026Article
- EngineeringMetabolic engineering communications · 2026Article
- Engineering mixed sugar metabolic channels inSynthetic and systems biotechnology · 2026Article
- Engineering yeast for sustainable bioproduction of tryptophan-derived aromatic compounds.FEMS yeast research · 2026Review
- Article
- A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism inmSystems · 2025Article
- Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida.Journal of biological engineering · 2025Article
- Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain.Microbial biotechnology · 2025Article
- Redesigned Pathway forJACS Au · 2025Article
- Repurposing FDA-Approved Agents to Develop a PrototypePharmaceuticals (Basel, Switzerland) · 2025Article
- Efficient Synthesis ofMolecules (Basel, Switzerland) · 2025Article
- Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery.Current topics in medicinal chemistry · 2025Review
- Microbial Gatekeepers of Fertility in the Female Reproductive Microbiome of Cattle.International journal of molecular sciences · 2024Review
- Unlocking Nature's Rhythms: Insights into Secondary Metabolite Modulation by the Circadian Clock.International journal of molecular sciences · 2024Review
- Carbon dioxide valorization into resveratrol via lithoautotrophic fermentation using engineered Cupriavidus necator H16.Microbial cell factories · 2024Article
- Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities.ACS synthetic biology · 2024Review
- Identification of transporters involved in aromatic compounds tolerance through screening of transporter deletion libraries.Microbial biotechnology · 2024Article
- Nitrogen Nutrition Modulates the Response toPlants (Basel, Switzerland) · 2024Article
25 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites. Through metabolic engineering, the abundance of certain intermediates may be increased, while draining flux from other branches off the pathway. Often targets for genetic engineering lie beyond the shikimate pathway, altering flux deep in central metabolism. This has been extensively used to develop microbial production systems for a variety of compounds valuable in chemical industry, including aromatic and non-aromatic acids like muconic acid,
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