Evidence map›Paper›PMID 29632774›Full record

ArticlePlastic and reconstructive surgery. Global open2017

Split Tolerance in a Murine Model of Heterotopic En Bloc Chest Wall Transplantation.

Byoungchol Oh, Georg J Furtmüller, Veronika Malek, Madeline L Fryer, Cory Brayton, Piotr Walczak, Miroslav Janowsky, Gerald Brandacher, Amir H Dorafshar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Tolerogenic Therapies in Cardiac Transplantation.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Efficacy of single-agent immunosuppressive regimens in a murine model of vascularized composite allotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Byoungchol OhDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Georg J FurtmüllerDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Veronika MalekDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Madeline L FryerDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Cory BraytonDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Piotr WalczakDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Miroslav JanowskyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Gerald BrandacherDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
Amir H DorafsharDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
University Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital and acquired chest wall deformities represent a significant challenge to functional reconstruction and may impact feasibility of heart transplantation for patients with end-stage organ failure. In the recent past, the concept of replacing like-with-like tissue by using vascularized composite allografts (VCA) has been enthusiastically employed for reconstruction of complex tissue defects.

methodsIn this study, we introduce a novel murine model for en bloc chest wall, heart, and thymus transplantation and thereby the use of complex tissue allografts for reconstruction of both chest wall defects and also end-stage organ failure. Additionally, this model allows us to study the features of combined vascularized bone marrow (VBM), thymus, and heart transplantation on allograft survival and function. Heterotopic chest wall, thymus, and heart transplants were performed in untreated syngeneic and allogeneic combinations and in allogeneic combinations treated with costimulation blockade (CTLA4-Ig and MR-1).

resultsIndefinite (ie, 150 d,

conclusionThus, this novel microsurgical model of VCA combined with solid organ transplantation is technically feasible and results in split tolerance when treated with costimulatory blockade.

Identifiers

PMID29632774
PMCPMC5889449
OpenAlexW2779207434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.