Evidence map›Paper›PMID 29632710›Full record

ArticleOncoimmunology

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer.

Friedrich H Schmitz-Winnenthal, Nicolas Hohmann, Thomas Schmidt, Lilli Podola, Tobias Friedrich, Heinz Lubenau, Marco Springer, Sébastien Wieckowski, Klaus M Breiner, Gerd Mikus and 9 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Friedrich H Schmitz-WinnenthalDepartment of General, Abdominal and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Nicolas HohmannClinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Thomas SchmidtDepartment of General, Abdominal and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Lilli PodolaRegensburg Center for Interventional Immunology (RCI), University Hospital Regensburg, Regensburg, Germany.
Tobias FriedrichDiagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Heinz LubenauVAXIMM GmbH, Mannheim, Germany.
Marco SpringerVAXIMM GmbH, Mannheim, Germany.
Sébastien WieckowskiVAXIMM AG, Basel, Switzerland.
Klaus M BreinerVAXIMM AG, Basel, Switzerland.
Gerd MikusClinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Markus W BüchlerDepartment of General, Abdominal and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Anne-Valerie KellerVAXIMM GmbH, Mannheim, Germany.
Ruhan KocDepartment of General, Abdominal and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Christoph SpringfeldMedical Oncology, National Center for Tumor Diseases, Heidelberg, Germany.
Phillip KnebelDepartment of General, Abdominal and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Mariana BucurRegensburg Center for Interventional Immunology (RCI), University Hospital Regensburg, Regensburg, Germany.
Lars GrenacherDiagnostic Munich, Diagnostic Prevention and Imaging Center, Munich, Germany.
Walter E HaefeliClinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Philipp BeckhoveRegensburg Center for Interventional Immunology (RCI), University Hospital Regensburg, Regensburg, Germany.
Heidelberg University · DEVaximm (Germany) · DEUniversity Hospital Regensburg · DECentre de Recherche en Sciences et Technologies de l'Information et de la Communication · FRNational Center for Tumor Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated

Indexed as

anti-angiogenesishuman CD8+ T cellsimmune-oncologyoral vaccinationpancreatic cancerSalmonella typhiVEGFR2

Identifiers

PMID29632710
PMCPMC5889207
OpenAlexW2607471147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.