Evidence map›Paper›PMID 29632645›Full record

ArticleOncotarget2018

Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location.

Lorena Brandariz, María Arriba, Juan Luis García, Juana María Cano, Daniel Rueda, Eduardo Rubio, Yolanda Rodríguez, Jessica Pérez, Alfredo Vivas, Carmen Sánchez and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.Cellular and molecular gastroenterology and hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Lorena BrandarizSurgery Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
María ArribaBiochemistry Department, Gregorio Marañón University Hospital, Madrid, Spain.
Juan Luis GarcíaMolecular Medicine Unit, Department of Medicine, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Juana María CanoOncology Department, Ciudad Real General Hospital, Ciudad Real, Spain.
Daniel RuedaMolecular Biology Laboratory, "12 de Octubre" Universitary Hospital, Madrid, Spain.
Eduardo RubioSurgery Department, "12 de Octubre" Universitary Hospital, Madrid, Spain.
Yolanda RodríguezPathology Department, "12 de Octubre" Universitary Hospital, Madrid, Spain.
Jessica PérezMolecular Medicine Unit, Department of Medicine, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Alfredo VivasSurgery Department, "12 de Octubre" Universitary Hospital, Madrid, Spain.
Carmen SánchezSurgery Department, "12 de Octubre" Universitary Hospital, Madrid, Spain.
Sandra TapialDigestive Cancer Research Group, "12 de Octubre" Research Institute, Madrid, Spain.
Laura PenaFamilial Cancer Clinical Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Mariano García-ArranzHealth Research Institute, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Damián García-OlmoSurgery Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Miguel UriosteFamilial Cancer Clinical Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Rogelio González-SarmientoMolecular Medicine Unit, Department of Medicine, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
José PereaSurgery Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Hospital Universitario Fundación Jiménez Díaz · ESCentro de Investigación del Cáncer · ESHospital Universitario 12 De Octubre · ESHospital General Universitario de Ciudad Real · ESHospital General Universitario Gregorio Marañón · ESResearch Institute Hospital 12 de Octubre · ESSpanish National Cancer Research Centre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC).

resultsRight colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and MATERIALS AND

methodsWe analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon.

conclusionsCategorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC.

Indexed as

chromosomal instabilitycolon locationCpG island methylator phenotypelate-onset colorectal cancermicrosatellite instability

Identifiers

PMID29632645
PMCPMC5880605
OpenAlexW2791237871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.