Evidence map›Paper›PMID 29632539›Full record

ArticleFrontiers in immunology2018

Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages.

Defne Bayik, Debra Tross, Dennis M Klinman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

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  9. Antitumor efficacy of multi-targetJournal of biomedical research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Defne BayikCancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD, United States.
Debra TrossCancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD, United States.
Dennis M KlinmanCancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD, United States.
National Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocytic myeloid-derived suppressor cells (mMDSC) accumulate within tumors where they create an immunosuppressive milieu that inhibits the activity of cytotoxic T and NK cells thereby allowing cancers to evade immune elimination. The toll-like receptors 7/8 agonist R848 induces human mMDSC to mature into inflammatory macrophage (MAC

Indexed as

Cell DifferentiationCells, CulturedCytokinesCytotoxicity, ImmunologicGene Expression ProfilingHumansImidazolesImmune ToleranceImmunotherapyInflammationInflammation MediatorsMonocytesMyeloid-Derived Suppressor CellsNeoplasmsNF-kappa BSTAT4 Transcription FactorCytokinesImidazolesInflammation MediatorsNF-kappa BresiquimodSTAT4 Transcription FactorIFNγinflammatory macrophagemyeloid-derived suppressor cellsNF-κBSTAT4TNFα

Identifiers

PMID29632539
PMCPMC5879147
OpenAlexW2791232925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.