Evidence map›Paper›PMID 29632530›Full record

ArticleFrontiers in immunology2018

Ezh2 Regulates Activation-Induced CD8

Guobing Chen, Kalpana Subedi, Sayantan Chakraborty, Alexie Sharov, Jian Lu, Jaekwan Kim, Xiaofan Mi, Robert Wersto, Myong-Hee Sung, Nan-Ping Weng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Guobing ChenLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Kalpana SubediLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Sayantan ChakrabortyTranscription Systems Dynamics and Biology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Alexie SharovLaboratory of Genetics and Genomics, National Institute on Aging (NIH), Baltimore, MD, United States.
Jian LuLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Jaekwan KimLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Xiaofan MiLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Robert WerstoFlow Cytometry Unit, National Institute on Aging (NIH), Baltimore, MD, United States.
Myong-Hee SungTranscription Systems Dynamics and Biology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
Nan-Ping WengLymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging (NIH), Baltimore, MD, United States.
National Institute on Aging · USSystems Dynamics (United States) · US

Funding

Functional decoding of signaling dynamics in single immune cellsZIAAG000380 · NIA · NATIONAL INSTITUTE ON AGING · PI SUNG, MYONG-HEE · 2016 to 2025
$29.0M
Mechanisms Of Transcriptional Regulation in Memory lymphocyte Response and AgingZIAAG000757 · NIA · NATIONAL INSTITUTE ON AGING · PI WENG, NAN-PING PETER · 2009 to 2025
$7.9M
TCR repertoire: size, diversity, and functionZIAAG000499 · NIA · NATIONAL INSTITUTE ON AGING · PI WENG, NAN-PING PETER · 2017 to 2025
$3.6M
6 · The paper itself

Abstract

Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8

Indexed as

AnimalsAntigensApoptosisCD8-Positive T-LymphocytesCell CycleCell ProliferationCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p57Enhancer of Zeste Homolog 2 ProteinListeria monocytogenesListeriosisMice, KnockoutOvalbuminAntigensCdkn1c protein, mouseCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p57Enhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseOvalbuminCD8+ T cellsCDKN1CCDKN2Acell cycleEZH2

Identifiers

PMID29632530
PMCPMC5879148
OpenAlexW2792926177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.