Evidence map›Paper›PMID 29632482›Full record

ArticleFrontiers in computational neuroscience2018

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain.

Prasad Shirvalkar, Tess L Veuthey, Heather E Dawes, Edward F Chang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in computational neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04958096 (Adjunct Cortical Stimulation With Deep Brain Stimulation), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04958096 narecruitingnot on this mapstarted 2021, after this paper: background citation

Adjunct Cortical Stimulation With Deep Brain Stimulation (DBS) to Treat Obsessive Compulsive Disorder (OCD)

TypeinterventionalSponsorAndrew Moses Lee, MD, PhDRan2021 to 2026Enrolled15ConditionsObsessive-Compulsive DisorderArmsStandard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 74 citations in OpenAlex.

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  20. The future of brain circuit-targeted therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Prasad ShirvalkarPain Management Division, Departments of Neurology and Anesthesiology, University of California, San Francisco, San Francisco, CA, United States.
Tess L VeutheyNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, United States.
Heather E DawesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USNeurological Surgery · US

Funding

NINDS NIH HHS L30 NS113218
6 · The paper itself

Abstract

Pain is a subjective experience that alerts an individual to actual or potential tissue damage. Through mechanisms that are still unclear, normal physiological pain can lose its adaptive value and evolve into pathological chronic neuropathic pain. Chronic pain is a multifaceted experience that can be understood in terms of somatosensory, affective, and cognitive dimensions, each with associated symptoms and neural signals. While there have been many attempts to treat chronic pain, in this article we will argue that feedback-controlled 'closed-loop' deep brain stimulation (DBS) offers an urgent and promising route for treatment. Contemporary DBS trials for chronic pain use "open-loop" approaches in which tonic stimulation is delivered with fixed parameters to a single brain region. The impact of key variables such as the target brain region and the stimulation waveform is unclear, and long-term efficacy has mixed results. We hypothesize that chronic pain is due to abnormal synchronization between brain networks encoding the somatosensory, affective and cognitive dimensions of pain, and that multisite, closed-loop DBS provides an intuitive mechanism for disrupting that synchrony. By (1) identifying biomarkers of the subjective pain experience and (2) integrating these signals into a state-space representation of pain, we can create a predictive model of each patient's pain experience. Then, by establishing how stimulation in different brain regions influences individual neural signals, we can design real-time, closed-loop therapies tailored to each patient. While chronic pain is a complex disorder that has eluded modern therapies, rich historical data and state-of-the-art technology can now be used to develop a promising treatment.

Indexed as

affectivechronic painclosed-loop stimulationcognitivecontrol theorydeep brain stimulationneuropathic painsomatosensory

Identifiers

PMID29632482
PMCPMC5879131
OpenAlexW2789639386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.