ArticleScientific reports2018
Metabolomics and proteomics reveal drought-stress responses of leaf tissues from spring-wheat.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 295 citations in OpenAlex.
- Abiotic Stress in Crop Production.International journal of molecular sciences · 2023Pooled it
- Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake.Molecular nutrition & food research · 2019Trial
- The progression of leaf senescence is gated by the cytosolic arginine pool.Nature plants · 2026Article
- Multi-Omics Dissection of Drought Stress Responses in Crops: From Molecular Regulatory Networks to Climate-Resilient Breeding Applications.International journal of molecular sciences · 2026Review
- Integrated morpho-physiological, metabolomic and transcriptomic profiling uncovers ethylene-mediated metabolic regulation shaping drought resilience in wheat.BMC plant biology · 2026Article
- Metabolic response strategies of spring wheat under osmotic stress.Frontiers in plant science · 2026Article
- The effect of spraying tryptophan on the physiological characteristics of the periwinkle plant (Catharanthus roseus L.) under drought stress.BMC plant biology · 2025Article
- Effects of nitrogen allocation and photosynthetic proteins response in peanut leaves on photosynthesis under conditions of water scarcity and nitrogen deficiency.BMC plant biology · 2025Article
- Proteomic Analysis of Mechanical Injury Effects in Papaya Fruit at Two Maturity Stages.Proteomes · 2025Article
- Utilizing Multi-Omics Analysis to Elucidate the Molecular Mechanisms of Oat Responses to Drought Stress.Plants (Basel, Switzerland) · 2025Article
- Deciphering nutrient stress in plants: integrative insight from metabolomics and proteomics.Functional & integrative genomics · 2025Review
- Review
- Polymeric Gluten Proteins as Climate-Resilient Markers of Quality: Can LC-MS/MS Provide Valuable Information about Spring Wheat Grown in Diverse Climates?Journal of agricultural and food chemistry · 2025Article
- Article
- Integration of metabolic and transcriptomic analyses for revealing the galactose metabolism of tobacco (Frontiers in plant science · 2025Article
- Transcriptome analysis of historic olives reveals stress-specific biomarkers.Frontiers in plant science · 2025Article
- Exploring physiological and molecular dynamics of drought stress responses in plants: challenges and future directions.Frontiers in plant science · 2025Review
- Integrative physiological, biochemical, and metabolomic analyses reveal complex drought and zinc stress tolerance in a novelFrontiers in plant science · 2025Article
- Multi-Trait Index-Based Selection of Drought Tolerant Wheat: Physiological and Biochemical Profiling.Plants (Basel, Switzerland) · 2024Article
- Drought-tolerant wheat for enhancing global food security.Functional & integrative genomics · 2024Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To reveal the integrative biochemical networks of wheat leaves in response to water deficient conditions, proteomics and metabolomics were applied to two spring-wheat cultivars (Bahar, drought-susceptible; Kavir, drought-tolerant). Drought stress induced detrimental effects on Bahar leaf proteome, resulting in a severe decrease of total protein content, with impairments mainly in photosynthetic proteins and in enzymes involved in sugar and nitrogen metabolism, as well as in the capacity of detoxifying harmful molecules. On the contrary, only minor perturbations were observed at the protein level in Kavir stressed leaves. Metabolome analysis indicated amino acids, organic acids, and sugars as the main metabolites changed in abundance upon water deficiency. In particular, Bahar cv showed increased levels in proline, methionine, arginine, lysine, aromatic and branched chain amino acids. Tryptophan accumulation via shikimate pathway seems to sustain auxin production (indoleacrylic acid), whereas glutamate reduction is reasonably linked to polyamine (spermine) synthesis. Kavir metabolome was affected by drought stress to a less extent with only two pathways significantly changed, one of them being purine metabolism. These results comprehensively provide a framework for better understanding the mechanisms that govern plant cell response to drought stress, with insights into molecules that can be used for crop improvement projects.
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