Evidence map›Paper›PMID 29632382›Full record

SynthesisNature genetics2018

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, Audrey Y Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, N William Rayner and 233 more

Abstract readMeta-AnalysisValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Trial
  12. Trial
  13. Trial
  14. Article
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  18. Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.medRxiv : the preprint server for health sciences · 2026
    Article
  19. Article
  20. Article

214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

243 authors.

Anubha MahajanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. anubha@well.ox.ac.uk.ORCID http://orcid.org/0000-0001-5585-3420
Jennifer WesselDepartments of Epidemiology and Medicine, Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA.
Sara M WillemsMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8301-9297
Neil R RobertsonWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Audrey Y ChuNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Wei GanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Hidetoshi KitajimaWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Daniel TaliunDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
N William RaynerWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yingchang LuCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Man LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Richard A JensenCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Yao HuInstitute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Shaofeng HuoInstitute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Kurt K LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Bram Peter PrinsDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Jason FlannickProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vassily Vladimirovich TrubetskoyDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jasmina KravicDepartment of Clinical Sciences, Diabetes, and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Young Jin KimCenter for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Denis V RybinDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Karina MeidtnerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Tibor V VargaDepartment of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jin LiDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Ping AnDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stefan GustafssonDepartment of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Giovanni MalerbaSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.
Ayse DemirkanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Juan Fernandez TajesWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Valgerdur SteinthorsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Matthias WuttkeInstitute of Genetic Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cécile LecoeurCNRS, UMR 8199, Lille University, Lille Pasteur Institute, Lille, France.
Michael PreussCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Marielisa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Heather M HighlandHuman Genetics Center, University of Texas Graduate School of Biomedical Sciences at Houston, University of Texas Health Science Center at Houston, Houston, TX, USA.
Anne E JusticeDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Dajiang J LiuDepartment of Public Health Sciences, Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Gina Marie PelosoProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ExomeBP Consortium
MAGIC Consortium
GIANT Consortium
Saima AfaqDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Shoaib AfzalDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Emma AhlqvistDepartment of Clinical Sciences, Diabetes, and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Peter AlmgrenDepartment of Clinical Sciences, Hypertension, and Cardiovascular Disease, Lund University, Malmö, Sweden.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Lia B BangDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Alain G BertoniDepartment of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Cristina BombieriSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ivan BrandslundInstitute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Jennifer A BrodyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Noël P BurttProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Mickaël CanouilCNRS, UMR 8199, Lille University, Lille Pasteur Institute, Lille, France.
Yii-Der Ida ChenDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.
Cramer ChristensenMedical Department, Lillebælt Hospital Vejle, Vejle, Denmark.
Sophie V EastwoodInstitute of Cardiovascular Science, University College London, London, UK.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité, University Medicine Berlin, Berlin, Germany.
Krista FischerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Giovanni GambaroInstitute of Internal and Geriatric Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hugoline G de HaanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Sophie HackingerDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Yang HaiDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sohee HanCenter for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Anne Tybjærg-HansenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Marie-France HivertDiabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Bo IsomaaMalmska Municipal Health Care Center and Hospital, Jakobstad, Finland.
Susanne JägerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Marit E JørgensenSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Torben JørgensenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Annemari KäräjämäkiDepartment of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
Bong-Jo KimCenter for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Sung Soo KimCenter for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Heikki A KoistinenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Peter KovacsIntegrated Research and Treatment (IFB) Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Jennifer KriebelGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Kristi LällEstonian Genome Center, University of Tartu, Tartu, Estonia.
Leslie A LangeDepartment of Medicine, Division of Bioinformatics and Personalized Medicine, University of Colorado Denver, Aurora, CO, USA.
Jung-Jin LeeDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Huaixing LiInstitute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Keng-Hung LinDepartment of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan.
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jun LiuDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marie LohDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Vasiliki MamakouDromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Roberta McKean-CowdinDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Girish NadkarniDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matt NevilleOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Sune F NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Ioanna NtallaWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Wolfgang RathmannGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Line RodeDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Olov RolandssonDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Sebastian SchönherrDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kerrin S SmallDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tanya M TeslovichDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Barbara ThorandGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Adrienne TinWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Anke TönjesDepartment of Medicine, University of Leipzig, Leipzig, Germany.
Anette VarboDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Daniel R WitteDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Pranav YajnikDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jie YaoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Loïc YengoCNRS, UMR 8199, Lille University, Lille Pasteur Institute, Lille, France.
Robin YoungMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Philippe AmouyelInstitut Pasteur de Lille, INSERM U1167, Université Lille Nord de France, Lille, France.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rajiv ChowdhuryDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Francis S CollinsGenome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
George DedoussisDepartment of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marco M FerrarioResearch Centre on Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Jean FerrièresINSERM, UMR 1027, Toulouse, France.
Jose C FlorezDiabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Philippe FrossardCenter for Non-Communicable Diseases, Karachi, Pakistan.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA.
Susan R HeckbertCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Joanna M M HowsonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Martin IngelssonDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Frank KeeUKCRC Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, UK.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Satu MännistöNational Institute for Health and Welfare, Helsinki, Finland.
Thomas MeitingerInstitute of Human Genetics, Technische Universität München, Munich, Germany.
Olle MelanderDepartment of Clinical Sciences, Hypertension, and Cardiovascular Disease, Lund University, Malmö, Sweden.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Marie MoitryDepartment of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France.
Andrew D MorrisClinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Alison D MurrayAberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences, and Nutrition, University of Aberdeen, Aberdeen, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Marju Orho-MelanderDepartment of Clinical Sciences, Diabetes, and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden.
Katharine R OwenOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland.
Annette PetersDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Michael A ProvinceDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Paul M RidkerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Fernando RivadineiraDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Anders H RosengrenDepartment of Clinical Sciences, Diabetes, and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Wayne H-H SheuDepartment of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Rob SladekMcGill University and Génome Québec Innovation Centre, Montreal, QC, Canada.
Blair H SmithDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
André G UitterlindenDepartment of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Rohit VarmaUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Matthias BlüherIntegrated Research and Treatment (IFB) Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John Campbell ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Daniel I ChasmanDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Cornelia van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Josée DupuisNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Paul W FranksDepartment of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Philippe FroguelCNRS, UMR 8199, Lille University, Lille Pasteur Institute, Lille, France.
Harald GrallertGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Leif GroopDepartment of Clinical Sciences, Diabetes, and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Bok-Ghee HanCenter for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andrew T HattersleyUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Erik IngelssonDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jaspal Singh KoonerDepartment of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK.
Anna KöttgenInstitute of Genetic Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kari KuulasmaaInstitute of Human Genetics, Technische Universität München, Munich, Germany.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Xu LinInstitute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Yongmei LiuDepartment of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan MarchiniWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Dennis Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Colin N A PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Rainer RauramaaFoundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Nicole SoranzoDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Timothy D SpectorDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.
Kari StefanssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Michael StumvollDivisions of Endocrinology and Nephrology, University Hospital Leipzig, Leipzig, Germany.
Unnur ThorsteinsdottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tiinamaija TuomiFolkhälsan Research Centre, Helsinki, Finland.
Jaakko TuomilehtoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Eleftheria ZegginiDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Inês BarrosoDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5800-4520
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
James B MeigsGeneral Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Danish SaleheenDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6193-020X
Andrew P MorrisWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. jrotter@labiomed.org.
Mark I McCarthyWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. mark.mccarthy@drl.ox.ac.uk.ORCID http://orcid.org/0000-0002-4393-0510

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
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6 · The paper itself

Abstract

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10

Indexed as

AllelesChromosome MappingDiabetes Mellitus, Type 2Exome SequencingFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleWhite People

Identifiers

PMID29632382
PMCPMC5898373

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