ArticleNature neuroscience2018
A hypothalamic circuit for the circadian control of aggression.
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Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
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Who cites it
87 citing papers in PubMed, 153 citations in OpenAlex.
- Defining Clock Neurons Within Distributed Circadian Circuits Through Multiscale Technologies.Journal of biological rhythms · 2026Review
- Oxytocin promotes socially triggered cataplexy.Nature neuroscience · 2026Article
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026Article
- Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026Article
- Behavioral and brain-wide neural signatures of sundowning in Alzheimer's disease.Research square · 2026Article
- A hypothalamic circuit for circadian regulation of corticosterone secretion.Nature communications · 2026Article
- A GABAergic neural circuit from the suprachiasmatic nucleus to DG drives cognitive impairment in migraine mice.The journal of headache and pain · 2026Article
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep.Neurology international · 2025Article
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- Circadian rhythms in sexual behavior and their influence on reproductive outcomes in mice.bioRxiv : the preprint server for biology · 2025Article
- Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review.Journal of clinical medicine · 2025Review
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- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Circadian rhythms are more resilient to pacemaker neuron disruption in female Drosophila.PLoS biology · 2025Article
- GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity.The European journal of neuroscience · 2024Article
- Sustainable poultry practices: integrating green light interventions to control pecking in chicken.BMC veterinary research · 2024Article
- Brexpiprazole: A new option in treating agitation in Alzheimer's dementia-Insights from transgenic mouse models.Neuropsychopharmacology reports · 2024Article
- Independent inhibitory control mechanisms for aggressive motivation and action.Nature neuroscience · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 5 institutions in 5 countries.
William D ToddDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Henning FenselauDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Joshua L WangDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3490-6957
Rong ZhangDivision of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7906-6210
Natalia L MachadoDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Anne VennerDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7481-3248
Rebecca Y BroadhurstDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Satvinder KaurDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Timothy LynaghDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4888-4098
David P OlsonDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Bradford B LowellDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Patrick M FullerDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Clifford B SaperDepartment of Neurology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. csaper@bidmc.harvard.edu.ORCID 0000-0002-5788-3014
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USUniversidade Federal de Minas Gerais · BRUniversity of Copenhagen · DKUniversity of Michigan · US
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MWakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MTRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1991 to 2018
$23.1MTRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MNeurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0MMolecular-Genetic Dissection of Subcortical Circuitry Regulating ArousalR01NS073613 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Patrick M Fuller · 2011 to 2026
$5.5MCircuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8MHypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8MBrainstem regulation of sleepR01NS092652 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FULLER, PATRICK M · 2015 to 2019
$2.2MNHLBI NIH HHS P01 HL095491NHLBI NIH HHS T32 HL007901NIA NIH HHS P01 AG009975NIA NIH HHS R03 AG062883NIDDK NIH HHS K08 DK071561NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401NINDS NIH HHS F32 NS084582NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS073613NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS092652NINDS NIH HHS R01 NS103161
Abstract
'Sundowning' in dementia and Alzheimer's disease is characterized by early-evening agitation and aggression. While such periodicity suggests a circadian origin, whether the circadian clock directly regulates aggressive behavior is unknown. We demonstrate that a daily rhythm in aggression propensity in male mice is gated by GABAergic subparaventricular zone (SPZ
Indexed as
AggressionAnimalsBrain MappingCircadian RhythmCorticosteroneExcitatory Postsynaptic Potentialsgamma-Aminobutyric AcidHypothalamusMaleMiceMice, Inbred C57BLNeural PathwaysOptogeneticsParaventricular Hypothalamic NucleusSuprachiasmatic NucleusVasoactive Intestinal PeptideCorticosteronegamma-Aminobutyric AcidVasoactive Intestinal Peptide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.