Evidence map›Paper›PMID 29632347›Full record

ArticleScientific reports2018

Positive Surgical Margins in the 10 Most Common Solid Cancers.

Ryan K Orosco, Viridiana J Tapia, Joseph A Califano, Bryan Clary, Ezra E W Cohen, Christopher Kane, Scott M Lippman, Karen Messer, Alfredo Molinolo, James D Murphy and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Impact of surgical margins status on survival outcomes in oral cavity squamous cell carcinoma: a systematic review and meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
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  10. Fluorescent Molecular Imaging Can Improve Intraoperative Sentinel Margin Detection in Oral Squamous Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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  15. Positive surgical margins after robot-assisted radical prostatectomy Long-term oncologic consequences.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
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  19. Translation of Intraoperative Molecular Imaging for Clinical Use.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ryan K OroscoDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.ORCID 0000-0002-7885-4327
Viridiana J TapiaDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.
Joseph A CalifanoDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.
Bryan ClaryDepartment of Surgery, University of California, San Diego, CA, USA.
Ezra E W CohenMoores Cancer Center, University of California, San Diego, CA, USA.
Christopher KaneMoores Cancer Center, University of California, San Diego, CA, USA.
Scott M LippmanMoores Cancer Center, University of California, San Diego, CA, USA.
Karen MesserMoores Cancer Center, University of California, San Diego, CA, USA.
Alfredo MolinoloMoores Cancer Center, University of California, San Diego, CA, USA.
James D MurphyDepartment of Radiation Medicine and Applied Sciences, San Diego, CA, USA.
John PangDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.
Assuntina SaccoMoores Cancer Center, University of California, San Diego, CA, USA.
Kathryn R TringaleDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.
Anne WallaceDepartment of Surgery, University of California, San Diego, CA, USA.
Quyen T NguyenDivision of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA. q1nguyen@ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications. We sought to compare PSM rates for the ten most common solid cancers in the United States, and to assess trends over time. Over 10 million patients were identified in the National Cancer Data Base from 1998-2012, and 6.5 million had surgical margin data. PSM rates were compared between two time periods, 1998-2002 and 2008-2012. PSM was positively correlated with tumor category and grade. Ovarian and prostate cancers had the highest PSM prevalence in women and men, respectively. The highest PSM rates for cancers affecting both genders were seen for oral cavity tumors. PSM rates for breast cancer and lung and bronchus cancer in both men and women declined over the study period. PSM increases were seen for bladder, colon and rectum, and kidney and renal pelvis cancers. This large-scale analysis appraises the magnitude of PSM in the United States in order to focus future efforts on improving oncologic surgical care with the goal of optimizing value and improving patient outcomes.

Indexed as

Cost-Benefit AnalysisFemaleHumansMaleMargins of ExcisionNeoplasm GradingNeoplasmsPrevalencePrognosisTreatment OutcomeUnited States

Identifiers

PMID29632347
PMCPMC5890246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.