Evidence map›Paper›PMID 29632334›Full record

ArticleNature chemistry2018

A [4Fe-4S]-Fe(CO)(CN)-L-cysteine intermediate is the first organometallic precursor in [FeFe] hydrogenase H-cluster bioassembly.

Guodong Rao, Lizhi Tao, Daniel L M Suess, R David Britt

Abstract read
In one paragraph

Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. A personal account on 25 years of scientific literature on [FeFe]-hydrogenase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Biosynthesis of the [FeFe] hydrogenase H-clusterDalton transactions (Cambridge, England : 2003) · 2021
    Review
  11. HydG, the "dangler" iron, and catalytic production of free CO and CNDalton transactions (Cambridge, England : 2003) · 2021
    Article
  12. Statistical analysis of ENDOR spectra.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Article
  14. Article
  15. Angewandte Chemie (International ed. in English) · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. [FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guodong RaoDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-8043-3436
Lizhi TaoDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9921-2297
Daniel L M SuessDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-0916-1973
R David BrittDepartment of Chemistry, University of California, Davis, CA, USA. rdbritt@ucdavis.edu.ORCID http://orcid.org/0000-0003-0889-8436

Funding

Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Mechanisms of Radical SAM Enzymes Probed by EPR SpectroscopyR01GM104543 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BRITT, R DAVID · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM104543NIGMS NIH HHS R35 GM126961
6 · The paper itself

Abstract

Biosynthesis of the [FeFe] hydrogenase active site (the 'H-cluster') requires the interplay of multiple proteins and small molecules. Among them, the radical S-adenosylmethionine enzyme HydG, a tyrosine lyase, has been proposed to generate a complex that contains an Fe(CO)

Indexed as

CysteineElectron Spin Resonance SpectroscopyHydrogenHydrogenaseIron-Sulfur ProteinsMolecular StructureOrganometallic CompoundsCysteineHydrogenHydrogenaseiron hydrogenaseIron-Sulfur ProteinsOrganometallic Compounds

Identifiers

PMID29632334
PMCPMC6380689

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.