Evidence map›Paper›PMID 29632329›Full record

ArticleNature immunology2018

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.

Quirin Hammer, Timo Rückert, Eva Maria Borst, Josefine Dunst, André Haubner, Pawel Durek, Frederik Heinrich, Gilles Gasparoni, Marina Babic, Adriana Tomic and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 405 citations in OpenAlex.

  1. Trial
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  4. Review
  5. Article
  6. Review
  7. Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. γδ T cells show distinct responses to CMV after stem cell transplantation.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  13. Review
  14. Article
  15. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  16. HLA-E-Directed Accumulation of KIRInternational journal of molecular sciences · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. The CD94/NKG2A-HLA-E Axis as a Target in Cancer Immunotherapy: A Critical Perspective.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review

209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 2 countries.

Quirin HammerInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.ORCID http://orcid.org/0000-0003-2968-6061
Timo RückertInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Eva Maria BorstInstitute for Virology, Hannover Medical School, Hannover, Germany.
Josefine DunstInflammation Biology, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
André HaubnerInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Pawel DurekCell Biology, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Frederik HeinrichTherapeutic Gene Regulation German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Gilles GasparoniDepartment of Genetics, University of Saarland, Saarbrücken, Germany.
Marina BabicInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Adriana TomicInstitute for Virology, Hannover Medical School, Hannover, Germany.
Gabriella PietraDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-7080-531X
Mikalai NienenMedical Clinic I, Marien Hospital Herne, Ruhr University Bochum, Herne, Germany.
Igor Wolfgang BlauDepartment of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jörg HofmannInstitute of Virology Charité, Universitätsmedizin Berlin, Berlin, Germany.
Il-Kang NaDepartment of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Immo PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-8789-9578
Christian KoeneckeInstitute of Immunology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-7025-1735
Philipp HemmatiDepartment of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nina BabelMedical Clinic I, Marien Hospital Herne, Ruhr University Bochum, Herne, Germany.
Renate ArnoldDepartment of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jörn WalterDepartment of Genetics, University of Saarland, Saarbrücken, Germany.
Kevin ThurleySystems Biology of Inflammation, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Mir-Farzin MashreghiTherapeutic Gene Regulation German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
Martin MesserleInstitute for Virology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-1227-3933
Chiara RomagnaniInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany. romagnani@drfz.de.ORCID http://orcid.org/0000-0002-5167-7463
Leibniz Association · DEMedizinische Hochschule Hannover · DECharité - Universitätsmedizin Berlin · DESaarland University · DEUniversitätsklinik Marien Hospital Herne · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEOspedale Policlinico San Martino · ITVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C

Indexed as

CytomegalovirusCytomegalovirus InfectionsHumansKiller Cells, NaturalNK Cell Lectin-Like Receptor Subfamily CViral ProteinsKLRC2 protein, humanNK Cell Lectin-Like Receptor Subfamily CUL40 glycoprotein, CytomegalovirusViral Proteins

Identifiers

PMID29632329
OpenAlexW2796894443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.