Evidence map›Paper›PMID 29632312›Full record

ArticleNature2018

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes.

Rati Verma, Kurt M Reichermeier, A Maxwell Burroughs, Robert S Oania, Justin M Reitsma, L Aravind, Raymond J Deshaies

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Regulation of cellular proteostasis via mitochondrial protein import.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  2. Review
  3. Review
  4. A Deep-Learning Atlas of XPO1-Mediated Nuclear Export at Proteome Scale.bioRxiv : the preprint server for biology · 2026
    Article
  5. Ribosome-associated quality control and related mechanisms.Nature structural & molecular biology · 2026
    Review
  6. Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Interpreting ribosome dynamics during mRNA translation.The Journal of biological chemistry · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Mitochondrial protein import stress.Nature cell biology · 2025
    Review
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rati VermaHoward Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.
Kurt M ReichermeierDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
A Maxwell BurroughsNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Robert S OaniaHoward Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.
Justin M ReitsmaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
L AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. aravind@ncbi.nlm.nih.gov.
Raymond J DeshaiesHoward Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA. rdeshaie@amgen.com.

Funding

Evolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3M
Intramural NIH HHS Z99 LM999999
6 · The paper itself

Abstract

Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences

Indexed as

Amino Acid SequenceBiocatalysisCarboxylic Ester HydrolasesCarrier ProteinsCatalytic DomainGlutamineHumansNucleocytoplasmic Transport ProteinsPoint MutationProteasome Endopeptidase ComplexRibosomesRibosome Subunits, Large, EukaryoticRNA-Binding ProteinsRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteinsaminoacyl-tRNA hydrolaseANKZF1 protein, humanATP dependent 26S proteaseCarboxylic Ester HydrolasesCarrier ProteinsCDC48 protein, S cerevisiaeGlutamineLtn1 protein, S cerevisiaeNPL4 protein, S cerevisiaeNucleocytoplasmic Transport ProteinsProteasome Endopeptidase ComplexRNA-Binding ProteinsRNA, TransferRqc1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsStaphylococcal Protein ATae2 protein, S cerevisiaeUbiquitin-Protein LigasesUFD1 protein, S cerevisiaeValosin Containing ProteinVesicular Transport ProteinsVms1 protein, S cerevisiae

Identifiers

PMID29632312
PMCPMC6226276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.