ArticleNature communications2018
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers, 3 of them syntheses that pooled it.
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55citing papers in PubMed, 3 pooled it
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.Human molecular genetics · 2023Pooled it
- Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.Nature communications · 2019Pooled it
- Pooled it
- Cancer-associated fusion transcripts: mechanisms, functional roles, and clinical implications.Clinical and experimental medicine · 2026Review
- Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Leukemia risk factor ARID5B coordinates HDAC-mediated transcriptional repression.Nucleic acids research · 2026Article
- A Greek Case-Control Replication Study ofGenes · 2026Article
- RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia.medRxiv : the preprint server for health sciences · 2026Article
- Low frequency and rare coding variants affect susceptibility and progression of childhood acute lymphoblastic leukemia.Cancer cell international · 2026Article
- Review
- Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.Nature cancer · 2026Article
- Genetic susceptibility ofGlobal medical genetics · 2025Article
- Human genetic influences on early B cell development.Journal of human immunity · 2025Review
- Multi-step gene set analysis identified HTR3 family genes involving childhood acute lymphoblastic leukemia susceptibility.Archives of toxicology · 2025Article
- Methionine Synthase Reductase A66G Variant in Pediatric Acute Lymphoblastic Leukemia Patients.Journal of hematology · 2024Article
- Update on Recommendations for Surveillance for Children with Predisposition to Hematopoietic Malignancy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Review
- Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment.Nature communications · 2024Article
- Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators.Cell genomics · 2023Article
- Genetic Profiling of Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia.Journal of pediatric genetics · 2023Article
- Design and quality control of large-scale two-sample Mendelian randomization studies.International journal of epidemiology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
40 authors.
Jayaram VijayakrishnanDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
James StuddDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.ORCID http://orcid.org/0000-0002-7157-754X
Peter BroderickDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.ORCID http://orcid.org/0000-0002-8348-5829
Ben KinnersleyDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.ORCID http://orcid.org/0000-0003-1783-6296
Amy HolroydDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.ORCID http://orcid.org/0000-0001-9663-4611
Rajiv KumarDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120, Heidelberg, Germany.
James M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Christine J HarrisonWolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Anthony V MoormanWolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Ajay VoraDepartment of Haematology, Great Ormond Street Hospital, London, WC1N 3JH, UK.
Eve RomanDepartment of Health Sciences, University of York, York, YO10 5DD, UK.
Sivaramakrishna RachakondaDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120, Heidelberg, Germany.
Sally E KinseyDepartment of Paediatric and Adolescent Haematology and Oncology, Leeds General Infirmary, Leeds, LS1 3EX, UK.
Eamonn SheridanMedical Genetics Research Group, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK.
Pamela D ThompsonPaediatric and Familial Cancer Research Group, Institute of Cancer Sciences, St. Mary's Hospital, Manchester, M13 9WL, UK.
Julie A IrvingNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Rolf KoehlerDepartment of Human Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Per HoffmannDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn, D-53012, Bonn, Germany.
Markus M NöthenDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn, D-53012, Bonn, Germany.
Stefanie Heilmann-HeimbachDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn, D-53012, Bonn, Germany.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Douglas F EastonDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-2444-3247
Paul D P PharaohDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0001-8494-732X
Alison M DunningDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Laboratory, Cambridge, CB1 8RN, UK.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Frederico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4261-4583
Anthony SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Rosalind A EelesDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.ORCID http://orcid.org/0000-0002-3698-6241
ZSofia Kote-JaraiDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Kenneth MuirInstitute of Population Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-6429-988X
Nora PashayanDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-0843-2468
PRACTICAL Consortium
Mel GreavesCentre for Evolution and Cancer, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Martin ZimmermanDepartment of Paediatric Haematology and Oncology, Hannover Medical School, 30625, Hannover, Germany.
Claus R BartramDepartment of Human Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Martin SchrappeGeneral Paediatrics, University Hospital Schleswig-Holstein, 24105, Kiel, Germany.
Martin StanullaDepartment of Paediatric Haematology and Oncology, Hannover Medical School, 30625, Hannover, Germany.
Kari HemminkiDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120, Heidelberg, Germany.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK. richard.houlston@icr.ac.uk.
Funding
Cancer Research UK 15007Cancer Research UK 16491Cancer Research UK 16561Cancer Research UK 17528
Abstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10
Indexed as
ChildChild, PreschoolCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGlycosyltransferasesHLA AntigensHumansMaleOncogene Proteins, FusionPolymorphism, Single NucleotidePrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrognosisRisk FactorsCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinGlycosyltransferasesGTDC1 protein, humanHLA AntigensOncogene Proteins, FusionTEL-AML1 fusion protein
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