Evidence map›Paper›PMID 29632244›Full record

ArticleEMBO reports2018

Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury.

Jesica Frik, Juliane Merl-Pham, Nikolaus Plesnila, Nicola Mattugini, Jacob Kjell, Jonas Kraska, Ricardo M Gómez, Stefanie M Hauck, Swetlana Sirko, Magdalena Götz

Open access · hybridAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 131 citations in OpenAlex.

  1. Review
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  9. The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jesica FrikPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany.
Juliane Merl-PhamResearch Unit for Protein Science, Helmholtz Center Munich, Munich, Germany.
Nikolaus PlesnilaInstitute for Stroke and Dementia Research, Experimental Stroke Research, University of Munich Medical School, Munich, Germany.
Nicola MattuginiPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany.
Jacob KjellPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany.
Jonas KraskaPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany.
Ricardo M GómezInstituto de Biotecnología y Biología Molecular, UNLP-CONICET, La Plata, Argentina.
Stefanie M HauckResearch Unit for Protein Science, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0002-1630-6827
Swetlana SirkoPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany swetlana.sirko@med.uni-muenchen.de magdalena.goetz@helmholtz-muenchen.de.ORCID 0000-0001-5950-616X
Magdalena GötzPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany swetlana.sirko@med.uni-muenchen.de magdalena.goetz@helmholtz-muenchen.de.ORCID 0000-0003-1551-9203
Helmholtz Zentrum München · DECenter for Integrated Protein Science Munich · DEConsejo Nacional de Investigaciones Científicas y Técnicas · ARLudwig-Maximilians-Universität München · DEMunich Cluster for Systems Neurology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scar formation after brain injury is still poorly understood. To further elucidate such processes, here, we examine the interplay between astrocyte proliferation taking place predominantly at the vascular interface and monocyte invasion. Using genetic mouse models that decrease or increase reactive astrocyte proliferation, we demonstrate inverse effects on monocyte numbers in the injury site. Conversely, reducing monocyte invasion using CCR2

Indexed as

Cell ProliferationSignal TransductionAnimalsAstrocytesBrain InjuriesCells, CulturedCicatrixDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMonocytesProteomicsReceptors, Aryl HydrocarbonReceptors, CCR2Ccr2 protein, mouseReceptors, Aryl HydrocarbonReceptors, CCR2aryl hydrocarbon receptorastrogliosismonocytesscar formationsonic hedgehog pathwaytraumatic brain injury

Identifiers

PMID29632244
PMCPMC5934774
OpenAlexW2796848104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.