Evidence map›Paper›PMID 29632214›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Molecular spherical nucleic acids.

Hui Li, Bohan Zhang, Xueguang Lu, Xuyu Tan, Fei Jia, Yue Xiao, Zehong Cheng, Yang Li, Dagoberto O Silva, Henri S Schrekker and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. Review
  3. Formation and cellular uptake of Bleomycin saccharide decorated molecular spherical nucleic acids evaluated by time-resolved fluorescence spectroscopy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. The emerging era of structural nanomedicine.Nature reviews bioengineering · 2025
    Article
  13. Article
  14. Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids.Chembiochem : a European journal of chemical biology · 2025
    Article
  15. Article
  16. Photochemical Stabilization of Self-Assembled Spherical Nucleic Acids.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  17. DNA Dendron Tagging as a Universal Way to Deliver Proteins to Cells.Journal of the American Chemical Society · 2025
    Article
  18. In Vivo Interactions of Nucleic Acid Nanostructures With Cells.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui LiInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.
Bohan ZhangInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.
Xueguang LuDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Xuyu TanDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Fei JiaDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Yue XiaoInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.
Zehong ChengInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.
Yang LiInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.
Dagoberto O SilvaDepartment of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208-3113.
Henri S SchrekkerInstitute of Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91501-970, Brazil.
Ke ZhangInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China; k.zhang@northeastern.edu chadnano@northwestern.edu.ORCID 0000-0002-8142-6702
Chad A MirkinInstitute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China; k.zhang@northeastern.edu chadnano@northwestern.edu.ORCID 0000-0002-6634-7627

Funding

Project 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7M
Making Oligonucleotides Better Biopharmaceuticals by Steric ProtectionR01GM121612 · NIGMS · NORTHEASTERN UNIVERSITY · PI Ke Zhang · 2017 to 2026
$3.7M
NCI NIH HHS U54 CA199091NIGMS NIH HHS R01 GM121612
6 · The paper itself

Abstract

Herein, we report a class of molecular spherical nucleic acid (SNA) nanostructures. These nano-sized single molecules are synthesized from T

Indexed as

Models, MolecularNucleic Acid ConformationPoly TPoly Tgene regulationmolecular nanoconjugatesoligonucleotidesspherical nucleic acids

Identifiers

PMID29632214
PMCPMC5924931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.