ArticleProceedings of the National Academy of Sciences of the United States of America2018
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 97 citations in OpenAlex.
- KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.The EMBO journal · 2026Article
- Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility.Nature communications · 2026Article
- Prevalence of KDM6A deficiency in human cancer: A tissue microarray study on 18,570 cancers from 153 different tumor types.Virchows Archiv : an international journal of pathology · 2026Article
- NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress.The Journal of clinical investigation · 2026Article
- PTIP inhibits proliferation, migration, and angiogenesis of retinal microvascular endothelial cells in a high-glucose environment.In vitro cellular & developmental biology. Animal · 2026Article
- KDM6A deficiency promotes tumor progression and resistance to cabozantinib treatment in clear cell renal cell carcinoma.Scientific reports · 2025Article
- Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies.Oncogene · 2025Review
- Discovery and structural studies of histone demethylases.Frontiers in epigenetics and epigenomics · 2025Review
- Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.Molecular medicine (Cambridge, Mass.) · 2024Article
- TET2-STAT3-CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition.The Journal of experimental medicine · 2024Article
- Unveiling the Molecular Landscape of Pancreatic Ductal Adenocarcinoma: Insights into the Role of the COMPASS-like Complex.International journal of molecular sciences · 2024Review
- EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation.The Journal of experimental medicine · 2024Article
- Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression.Genes & diseases · 2024Article
- CRISPRingCancers · 2024Review
- Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma.Cancer research · 2024Article
- Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.Nature communications · 2023Article
- The role and function of CLU in cancer biology and therapy.Clinical and experimental medicine · 2023Review
- Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression.Neuro-oncology · 2023Article
- Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment.National science review · 2023Article
- Add fuel to the fire: Inflammation and immune response in lung cancer combined with COVID-19.Frontiers in immunology · 2023Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 8 institutions in 2 countries.
Qibiao WuState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Yahui TianInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
Jian ZhangState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Xinyuan TongState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Hsinyi HuangState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Shuai LiLaura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016.
Hong ZhaoInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
Ying TangState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Chongze YuanDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200031, China.
Kun WangKey Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
Zhaoyuan FangState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Lei GaoInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
Xin HuThe University of Texas Graduate School in Biomedical Sciences, Houston, TX 77030.
Fuming LiState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Zhen QinState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Shun YaoState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Ting ChenLaura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016.
Haiquan ChenDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200031, China.
Gong ZhangInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
Wanting LiuInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
Yihua SunDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200031, China.
Luonan ChenState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Kwok-Kin WongLaura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016.
Kai GeLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-7442-5138
Liang ChenInstitute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong 510632, China; chenliang@nibs.ac.cn hbji@sibcb.ac.cn.
Hongbin JiState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; chenliang@nibs.ac.cn hbji@sibcb.ac.cn.
Center for Excellence in Molecular Cell Science · CNJinan University · CNNYU Langone Health · USShanghai Medical College of Fudan University · CNChinese Academy of Sciences · CNNational Institutes of Health · USShanghaiTech University · CNThe University of Texas MD Anderson Cancer Center · US
Funding
Regulation of PPARgamma Expression and Adipogenesis by PTIP-Associated FactorsZIADK075003 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$17.6MAbstract
Lung cancer is the leading cause of cancer-related death worldwide. Inactivation of tumor suppressor genes (TSGs) promotes lung cancer malignant progression. Here, we take advantage of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated somatic gene knockout in a
Indexed as
CRISPR-Cas SystemsEpigenesis, GeneticGene Expression Regulation, NeoplasticAnimalsCell Transformation, NeoplasticHistone DemethylasesHumansLung NeoplasmsMiceMice, KnockoutNeoplasms, ExperimentalProto-Oncogene Proteins p21(ras)Tumor Suppressor ProteinsHistone DemethylasesHras protein, mouseProto-Oncogene Proteins p21(ras)Tumor Suppressor ProteinsUtx protein, mouseCRISPR/Cas9 in vivo knockoutEZH2 inhibitornon-small cell lung cancertumor suppressor genesUTX
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.