ArticleProceedings of the National Academy of Sciences of the United States of America2018
Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- A newly-processed Meicha (Food chemistry: X · 2026Article
- Sensory-Chemical Co-Dynamics inFoods (Basel, Switzerland) · 2025Article
- A Structure-Based Approach for Predicting Odor Similarity of Molecules via Docking Simulations with Human Olfactory Receptors.ACS omega · 2025Article
- Exploring LinearJournal of medicinal chemistry · 2025Article
- Convergent musk biosynthesis across host and microbiota in musk deer and muskrat.Zoological research · 2025Article
- Understanding the adsorption mechanism of geosmin, linalool, and o-cresol on Machilis hrabei olfactory receptor MhOR5 via statistical physics modeling and molecular docking simulation.Journal of molecular modeling · 2025Article
- Effect and mechanism of green and aldehyde aroma compounds from sweet orange on sucrose sweetness perception.Food chemistry: X · 2024Article
- Pyrfume: A window to the world's olfactory data.Scientific data · 2024Article
- Conserved pattern-based classification of human odorant receptor multigene family.Scientific reports · 2024Article
- Genome-wide pan-GPCR cell libraries accelerate drug discovery.Acta pharmaceutica Sinica. B · 2024Review
- Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular-Kidney-Metabolic Axis.Life (Basel, Switzerland) · 2024Review
- The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms.Acta pharmaceutica Sinica. B · 2023Review
- Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1.Journal of chemical information and modeling · 2023Article
- Odorant Receptor OR2C1 Is an Essential Modulator of Boar Sperm Capacitation by Binding with Heparin.International journal of molecular sciences · 2023Article
- Helix encoder: a compound-protein interaction prediction model specifically designed for class A GPCRs.Frontiers in bioinformatics · 2023Article
- Selectively Fluorinated Citronellol Analogues Support a Hydrogen Bonding Donor Interaction with the Human OR1A1 Olfactory Receptor.Organic letters · 2022Article
- Protective effects of muscone on traumatic spinal cord injury in rats.Annals of translational medicine · 2022Article
- High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote.Scientific reports · 2022Article
- Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors.International journal of molecular sciences · 2021Article
- Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease.Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 4 countries.
Lucky AhmedDepartment of Chemistry, Yale University, New Haven, CT 06520.ORCID 0000-0002-4205-9954
Yuetian ZhangDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, People's Republic of China.
Eric BlockDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222; eblock@albany.edu do1@st-andrews.ac.uk victor.batista@yale.edu hanyizhuang@sjtu.edu.cn.ORCID 0000-0002-4668-1687
Michael BuehlSchool of Chemistry, University of St. Andrews, North Haugh, KY16 9ST St. Andrews, Scotland.
Michael J CorrSchool of Chemistry, University of St. Andrews, North Haugh, KY16 9ST St. Andrews, Scotland.
Rodrigo A CormanichDepartment of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, SP 13083-970, Brazil.
Sivaji GundalaDepartment of Chemistry, University at Albany, State University of New York, Albany, NY 12222.
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
David O'HaganSchool of Chemistry, University of St. Andrews, North Haugh, KY16 9ST St. Andrews, Scotland; eblock@albany.edu do1@st-andrews.ac.uk victor.batista@yale.edu hanyizhuang@sjtu.edu.cn.
Mehmet OzbilDepartment of Chemistry, Yale University, New Haven, CT 06520.
Yi PanDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, People's Republic of China.
Sivakumar SekharanDepartment of Chemistry, Yale University, New Haven, CT 06520.
Nicholas TenDepartment of Chemistry, Yale University, New Haven, CT 06520.
Mingan WangDepartment of Applied Chemistry, College of Science, China Agricultural University, Haidian District, 100193 Beijing, People's Republic of China.
Mingyan YangSchool of Chemistry, University of St. Andrews, North Haugh, KY16 9ST St. Andrews, Scotland.
Qingzhi ZhangSchool of Chemistry, University of St. Andrews, North Haugh, KY16 9ST St. Andrews, Scotland.
Ruina ZhangDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, People's Republic of China.
Victor S BatistaDepartment of Chemistry, Yale University, New Haven, CT 06520; eblock@albany.edu do1@st-andrews.ac.uk victor.batista@yale.edu hanyizhuang@sjtu.edu.cn.
Hanyi ZhuangDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, People's Republic of China; eblock@albany.edu do1@st-andrews.ac.uk victor.batista@yale.edu hanyizhuang@sjtu.edu.cn.
University of St Andrews · GBYale University · USShanghai Jiao Tong University · CNAlbany State University · USChina Agricultural University · CNDuke University · USUniversidade Estadual de Campinas (UNICAMP) · BR
Funding
Computational and Biochemical Studies of Temperature Effects on Allostery in the Imidazole Glycerol Phosphate Synthase (IGPS) from T. maritimaR01GM106121 · NIGMS · YALE UNIVERSITY · PI BATISTA, VICTOR S, LORIA, JOSEPH P · 2014 to 2021
$2.3MPeripheral Odor Coding in MammalsR01DC014423 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2015 to 2019
$2.3MData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kNIDCD NIH HHS R01 DC014423NIGMS NIH HHS R01 GM106121NIH HHS S10 OD018164
Abstract
Understanding olfaction at the molecular level is challenging due to the lack of crystallographic models of odorant receptors (ORs). To better understand the molecular mechanism of OR activation, we focused on chiral (
Indexed as
Models, MolecularCycloparaffinsHEK293 CellsHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsMutagenesis, Site-DirectedProtein StabilityProtein Structure, SecondaryReceptors, OdorantCycloparaffinsmusconeOR1A1 protein, humanReceptors, Odorantmolecular dynamicsmuskodorant receptorolfactionquantum mechanics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.