ArticleProceedings of the National Academy of Sciences of the United States of America2018
Spontaneous oscillation and fluid-structure interaction of cilia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cilia dynamics create a dynamic barrier to penetration of the periciliary layer in human airway epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A mechanically consistent unified formulation for fluid-porous-structure-contact interaction.Computer methods in applied mechanics and engineering · 2024Article
- A multiscale biophysical model gives quantized metachronal waves in a lattice of beating cilia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The use of biophysical approaches to understand ciliary beating.Biochemical Society transactions · 2020Review
- Multiscale mechanics of mucociliary clearance in the lung.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Reorganization of complex ciliary flows around regeneratingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Cilia oscillations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Review
- Instability-driven oscillations of elastic microfilaments.Journal of the Royal Society, Interface · 2018Article
- Coordination of eukaryotic cilia and flagella.Essays in biochemistry · 2018Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exact mechanism to orchestrate the action of hundreds of dynein motor proteins to generate wave-like ciliary beating remains puzzling and has fascinated many scientists. We present a 3D model of a cilium and the simulation of its beating in a fluid environment. The model cilium obeys a simple geometric constraint that arises naturally from the microscopic structure of a real cilium. This constraint allows us to determine the whole 3D structure at any instant in terms of the configuration of a single space curve. The tensions of active links, which model the dynein motor proteins, follow a postulated dynamical law, and together with the passive elasticity of microtubules, this dynamical law is responsible for the ciliary motions. In particular, our postulated tension dynamics lead to the instability of a symmetrical steady state, in which the cilium is straight and its active links are under equal tensions. The result of this instability is a stable, wave-like, limit cycle oscillation. We have also investigated the fluid-structure interaction of cilia using the immersed boundary (IB) method. In this setting, we see not only coordination within a single cilium but also, coordinated motion, in which multiple cilia in an array organize their beating to pump fluid, in particular by breaking phase synchronization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.