Evidence map›Paper›PMID 29632086›Full record

ArticleGenes & development2018

Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of

Yuan Pan, Min Xiong, Ran Chen, Yu Ma, Courtney Corman, Meron Maricos, Urs Kindler, Marcus Semtner, Yi-Hsien Chen, Sonika Dahiya and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Reactive Astrocytes in Glioma: Emerging Opportunities and Challenges.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. RSC advances · 2024
    Article
  18. TheCancers · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Yuan Pan *Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Min Xiong *Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Ran ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Yu MaDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Courtney CormanDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Meron MaricosCellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Urs KindlerCellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Marcus SemtnerCellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.
Yi-Hsien ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Sonika DahiyaDivision of Neuropathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
David H GutmannDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0002-3127-5045
Washington University in St. Louis · USMax Delbrück Center · DE

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityR35NS097211 · NINDS · WASHINGTON UNIVERSITY · PI GUTMANN, DAVID H · 2017 to 2024
$5.7M
DEFINING RISK FACTORS FOR NF1-OPTIC GLIOMAR01CA214146 · NCI · WASHINGTON UNIVERSITY · PI GUTMANN, DAVID H · 2016 to 2020
$1.7M
Leveraging Genetically-Engineered Mice to Optimize Pediatric Glioma ManagementR01CA195692 · NCI · WASHINGTON UNIVERSITY · PI GUTMANN, DAVID H · 2015 to 2017
$1.7M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA195692NCI NIH HHS R01 CA214146NINDS NIH HHS R35 NS097211
6 · The paper itself

Abstract

Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (

Indexed as

AnimalsCells, CulturedChemokine CCL5Gene ExpressionGenes, Neurofibromatosis 1GliomaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMice, NudeMicrogliaReceptors, CCR2T-LymphocytesTumor MicroenvironmentCcl5 protein, mouseCcr2 protein, mouseChemokine CCL5Receptors, CCR2chemokinesmonocytestromatumor microenvironment

Identifiers

PMID29632086
PMCPMC5959233
OpenAlexW2798006575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.