Evidence map›Paper›PMID 29632078›Full record

ArticleMolecular and cellular biology2018

Regulation of Intestinal Epithelial Barrier Function by Long Noncoding RNA

Jun-Yao Wang, Yu-Hong Cui, Lan Xiao, Hee Kyoung Chung, Yunzhan Zhang, Jaladanki N Rao, Myriam Gorospe, Jian-Ying Wang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 62 citations in OpenAlex.

  1. Long Noncoding RNANon-coding RNA · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Mitochondrial Metabolism Meets LncRNA Biology: The Role of uc.173 in Intestinal Homeostasis.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders.Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2024
    Review
  12. Article
  13. Article
  14. MiR-106a-5p by TargetingAnimals : an open access journal from MDPI · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jun-Yao WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yu-Hong CuiCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hee Kyoung ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yunzhan ZhangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jaladanki N RaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, NIH, Baltimore, Maryland, USA.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA jywang@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Post-transcriptional Regulation Of Proliferative and Stress Response GenesZIAAG000511 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2025
$25.4M
Intestinal Mucosal Growth in Health & Surgical DiseasesR01DK057819 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2000 to 2026
$7.4M
Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
SURGICAL STUDIES ON MUCOSAL HOMEOSTASISI01BX000713 · VA · BALTIMORE VA MEDICAL CENTER · PI WANG, JIAN-YING · 2011 to 2024
–
BLRD VA I01 BX000713NIDDK NIH HHS R01 DK057819NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491
6 · The paper itself

Abstract

The mammalian intestinal epithelium establishes a selectively permeable barrier that supports nutrient absorption and prevents intrusion by noxious luminal substances and microbiota. The effectiveness and integrity of the barrier function are tightly regulated via well-controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control diverse cellular processes, but their roles in the regulation of gut permeability remain largely unknown. Here we report that the T-UCR

Indexed as

3' Untranslated RegionsAdherens JunctionsAnimalsCaco-2 CellsClaudin-1Conserved SequenceFemaleGene SilencingHumansIntestinal MucosaMaleMiceMice, Inbred C57BLMicroRNAsRNA, Long NoncodingRNA, Messenger3' Untranslated RegionsClaudin-1CLDN1 protein, humanCldn1 protein, mouseMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, mouseRNA, Long NoncodingRNA, Messengergut permeabilitymicroRNAposttranscriptional regulationseptic stresstight junctionT-UCRs

Identifiers

PMID29632078
PMCPMC6002690
OpenAlexW2981186849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.