Evidence map›Paper›PMID 29632076›Full record

ArticleThe Journal of biological chemistry2018

The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from

Katharina Weinhäupl, Martha Brennich, Uli Kazmaier, Joel Lelievre, Lluis Ballell, Alfred Goldberg, Paul Schanda, Hugo Fraga

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Total Synthesis of Mycoplanecin A.Organic letters · 2025
    Article
  5. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  6. Article
  7. Small-Angle X-Ray Scattering for Macromolecular Complexes.Advances in experimental medicine and biology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Marine Sediment RecoveredPolish journal of microbiology · 2020
    Article
  17. Could confounding the allosteric communication of biotic machinery be an alternative path to antibiotics?Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. An allosteric switch regulatesProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Katharina WeinhäuplFrom the Institut de Biologie Structurale, University of Grenoble Alpes-CEA, CNRS, IBS, 71 Avenue des Martyrs, CS 10090, 38044 Grenoble Cedex 9, France.
Martha Brennichthe European Molecular Biology Laboratory, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France.
Uli Kazmaierthe Institute of Organic Chemistry, Saarland University, Campus C4.2, 66123 Saarbrücken, Germany.
Joel Lelievrethe Diseases of the Developing World Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
Lluis Ballellthe Diseases of the Developing World Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
Alfred Goldbergthe Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and.
Paul SchandaFrom the Institut de Biologie Structurale, University of Grenoble Alpes-CEA, CNRS, IBS, 71 Avenue des Martyrs, CS 10090, 38044 Grenoble Cedex 9, France, paul.schanda@ibs.fr.
Hugo FragaFrom the Institut de Biologie Structurale, University of Grenoble Alpes-CEA, CNRS, IBS, 71 Avenue des Martyrs, CS 10090, 38044 Grenoble Cedex 9, France, hfraga@med.up.pt.
GlaxoSmithKline (Spain) · ESCEA Grenoble · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FREuropean Molecular Biology Laboratory · FRHarvard University · USInstitut de Biologie Structurale · FRSaarland University · DE

Funding

MOLECULAR CHAPERONES AND PROTEIN DEGRADATIONR01GM051923 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOLDBERG, ALFRED L · 1995 to 2020
$10.1M
NIGMS NIH HHS R01 GM051923
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsArginineBacterial ProteinsCell DeathCrystallography, X-RayGene Expression Regulation, BacterialHeat-Shock ProteinsIon TransportMycobacterium tuberculosisOligopeptidesOrganophosphorus CompoundsPhosphorylationProtein ConformationProtein DomainsTuberculosisAnti-Bacterial AgentsArginineBacterial ProteinsClpC1 protein, Mycobacterium tuberculosiscyclomarin AHeat-Shock ProteinsOligopeptidesOrganophosphorus Compoundsphospho-L-arginineantibiotic actionantibiotic resistancechaperoneMycobacterium tuberculosisnatural productnuclear magnetic resonance (NMR)proteasesmall-angle X-ray scattering (SAXS)

Identifiers

PMID29632076
PMCPMC5986217
OpenAlexW2797321272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.