Evidence map›Paper›PMID 29632066›Full record

ArticleThe Journal of biological chemistry2018

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Adiel Cohen, Aline Habib, Dana Laor, Sudhanshu Yadav, Martin Kupiec, Ronit Weisman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  5. TheCells · 2025
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  19. Review
  20. Subtelomeric Transcription and its Regulation.Journal of molecular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adiel CohenDepartment of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel.
Aline HabibDepartment of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.
Dana LaorDepartment of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.
Sudhanshu YadavDepartment of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel.
Martin KupiecDepartment of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.
Ronit WeismanDepartment of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel. Electronic address: ronitwe@openu.ac.il.
Open University of Israel · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conserved serine/threonine protein kinase target of rapamycin (TOR) is a major regulator of eukaryotic cellular and organismal growth and a valuable target for drug therapy. TOR forms the core of two evolutionary conserved complexes, TOR complex 1 (TORC1) and TORC2. In the fission yeast

Indexed as

Gene SilencingChromatinHeterochromatinHistonesMechanistic Target of Rapamycin Complex 2Multiprotein ComplexesPhosphorylationProtein Serine-Threonine KinasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsTelomereChromatinGad8 protein, S pombeHeterochromatinHistonesMechanistic Target of Rapamycin Complex 2Multiprotein ComplexesProtein Serine-Threonine KinasesSchizosaccharomyces pombe ProteinsAkt PKBEpe1gene expressiongene silencingheterochromatinmating-type locusPaf1 complexSchizosaccharomyces pombesubtelomeresTORC2

Identifiers

PMID29632066
PMCPMC5971458
OpenAlexW2796855833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.