Evidence map›Paper›PMID 29632022›Full record

ArticleBlood2018

Donor telomere length and causes of death after unrelated hematopoietic cell transplantation in patients with marrow failure.

Shahinaz M Gadalla, Geraldine Aubert, Tao Wang, Michael Haagenson, Stephen R Spellman, Lingxiao Wang, Hormuzd A Katki, Sharon A Savage, Stephanie J Lee

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genetic regulation ofmedRxiv : the preprint server for health sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Biomaterials as a Vital Frontier for Stem Cell-Based Tissue Regeneration.Frontiers in cell and developmental biology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Shahinaz M GadallaClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-3255-8143
Geraldine AubertTerry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.
Tao WangDivision of Biostatistics and.ORCID 0000-0002-2596-6843
Michael HaagensonCenter for International Blood and Marrow Transplant Research, Minneapolis, MN.
Stephen R SpellmanCenter for International Blood and Marrow Transplant Research, Minneapolis, MN.
Lingxiao WangBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Hormuzd A KatkiBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Sharon A SavageClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6006-0740
Stephanie J LeeCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0003-2600-6390
National Institutes of Health · USMedical College of Wisconsin · USNational Marrow Donor Program · USBC Cancer Agency · CA

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
Genetic Epidemiology of Telomere Maintenance and Cancer EtiologyZIACP010190 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$10.2M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Previous studies have suggested that longer donor leukocyte telomere length (TL) is associated with improved survival after hematopoietic cell transplantation (HCT) in severe aplastic anemia (SAA). This study aimed to determine whether cell-specific lymphocyte TL is associated with certain post-HCT causes of death. We used flow cytometry and fluorescence in situ hybridization to measure TL in donor total lymphocytes and subsets: naïve enriched T cells (CD45RA

Indexed as

Hematopoietic Stem Cell TransplantationImmune ToleranceUnrelated DonorsAdolescentAdultAnemia, AplasticBone MarrowCause of DeathChildChild, PreschoolFemaleHematopoietic Stem CellsHumansInfantMaleTreatment Outcome

Identifiers

PMID29632022
PMCPMC5969378
OpenAlexW2797388535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.