Evidence map›Paper›PMID 29632008›Full record

ArticleAntimicrobial agents and chemotherapy2018

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.

Theresa O'Malley, Torey Alling, Julie V Early, Heather A Wescott, Anuradha Kumar, Garrett C Moraski, Marvin J Miller, Thierry Masquelin, Philip A Hipskind, Tanya Parish

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. TargetingMicrobiology (Reading, England) · 2024
    Review
  5. Article
  6. Article
  7. Recent developments of imidazo[1,2-RSC medicinal chemistry · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action inFrontiers in cellular and infection microbiology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Theresa O'MalleyTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Torey AllingTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Julie V EarlyTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Heather A WescottTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Anuradha KumarTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Garrett C MoraskiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Marvin J MillerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Thierry MasquelinLilly Research Laboratories, Indianapolis, Indiana, USA.
Philip A HipskindLilly Research Laboratories, Indianapolis, Indiana, USA.
Tanya ParishTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@idri.org.
Infectious Disease Research Institute · USEli Lilly (United States) · USUniversity of Notre Dame · US

Funding

Design, Syntheses and Studies of Novel Antituberculosis AgentsR37AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2016 to 2025
$5.2M
Chemical probes of vulnerable pathways in antibiotic-resistant pathogensR01AI099188 · NIAID · ACCESS TO ADVANCED HEALTH INSTITUTE · PI PARISH, TANYA · 2012 to 2016
$3.7M
Design/Syntheses/Studies/Novel Antituberculosis AgentsR01AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2004 to 2014
$3.2M
NIAID NIH HHS R01 AI054193NIAID NIH HHS R01 AI099188NIAID NIH HHS R37 AI054193
6 · The paper itself

Abstract

The imidazopyridines are a promising new class of antitubercular agents with potent activity

Indexed as

Adenosine TriphosphateAntitubercular AgentsElectron Transport Complex IVImidazolesMicrobial Sensitivity TestsMutationMycobacterium tuberculosisPyridinesWhole Genome SequencingAdenosine TriphosphateAntitubercular AgentsElectron Transport Complex IVImidazolesimidazopyridinePyridinesantibacterialantibioticsATPcytochrome oxidasedrug discoverydrug resistancemycobacteriamycobacteriumrespiration

Identifiers

PMID29632008
PMCPMC5971599
OpenAlexW2796305858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.