ArticleReproductive biology and endocrinology : RB&E2018
The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome.
Article in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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34 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · 2018Pooled it
- Association of HDL-cholesterol related inflammatory ratios with reproductive outcomes in women with polycystic ovary syndrome undergoing frozen-thawed embryo transfer.Journal of ovarian research · 2026Article
- Integrative Mendelian Randomization and Whole-Blood Transcriptomic Analysis Implicate a Myeloid-Inflammation Axis in Polycystic Ovary Syndrome.International journal of women's health · 2026Article
- Correlation Analysis of the New Inflammatory Composite Index with the Degree of Coronary Artery Lesions in Elderly Patients.Clinical interventions in aging · 2026Article
- Inflammation and nutrition-derived indicators for predicting amputation risk in patients with type 2 diabetic foot ulcers.Frontiers in nutrition · 2026Article
- Monocyte-to-HDL ratio (MHR) as a novel biomarker: reference ranges and associations with inflammatory diseases and disease-specific mortality.Lipids in health and disease · 2025Article
- First-trimester inflammation and dyslipidemia in preterm delivery: the role of monocyte-to-HDL cholesterol ratio and lipid profiles.Irish journal of medical science · 2025Article
- The Relationship Between the Monocyte-to-High-Density Lipoprotein-Cholesterol Ratio and Disease Activity in Patients with Psoriatic Arthritis.European journal of rheumatology · 2025Article
- Inflammatory lipid biomarkers and transplant-free mortality risk in hepatitis B-related cirrhosis and hepatic encephalopathy.Frontiers in medicine · 2025Article
- Relationship Between Monocyte-to-High-Density Lipoprotein Cholesterol Ratio and Visceral Obesity in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Neutrophil to High-Density Lipoprotein Cholesterol Ratio With the Severity of New-Onset Coronary Artery Disease.Journal of inflammation research · 2025Article
- The Relationship between Vitamin D, Inflammatory Markers, and Insulin Resistance in Children.Nutrients · 2024Article
- Review
- Monocyte-to-high-density lipoprotein ratio and systemic immune-inflammation index: Potential parameters for the evaluation of disease activity and severity in Graves' ophthalmopathy?International ophthalmology · 2024Article
- Combinative predictive effect of left ventricular mass index, ratio of HDL and CRP for progression of chronic kidney disease in non-dialysis patient.International urology and nephrology · 2024Article
- Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis.Frontiers in cardiovascular medicine · 2024Article
- Age-Related Macular Degeneration in Patients with Androgenetic Alopecia: Could the Monocyte/HDL Ratio Be the Link?Dermatology practical & conceptual · 2023Article
- Insulin level, lipid profile, and HOMA index in lean and obese patients with polycystic ovary syndrome.Journal of medicine and life · 2023Article
- Predictive value of monocyte to high-density lipoprotein cholesterol ratio and tumor markers in colorectal cancer and their relationship with clinicopathological characteristics.World journal of surgical oncology · 2023Article
- The monocyte to high-density lipoprotein cholesterol ratio is a risk factor for frequent premature ventricular complexes: a retrospective cohort study.Lipids in health and disease · 2022Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress and inflammation. However, high-density lipoprotein cholesterol neutralizes the pro-inflammatory and pro-oxidant effects of monocytes. The aim of this study is to investigate whether monocyte counts to high-density lipoprotein cholesterol ratio can predict the inflammatory condition in patients with polycystic ovary syndrome.
methodsIn this cross-sectional study, a total of 124 women (61 of them with polycystic ovary syndrome and 63 age-matched healthy volunteers) were included in the study population. Obese polycystic ovary syndrome patients (n = 30) with a body mass index of ≥25 kg/m
resultsThe monocyte counts to high density lipoprotein cholesterol values in women with polycystic ovary syndrome were significantly higher than in control subjects (p = 0.0018). Moreover, a regression analysis revealed that body mass index, the homeostasis model assessment of insulin resistance and the high sensitivity C-reactive protein levels were confounding factors that affected the monocyte counts to high density lipoprotein cholesterol values. Additionally, a univariate and multivariate logistic regression analysis demonstrated that the increased monocyte counts to high density lipoprotein cholesterol values were more sensitive than the other known risk factors (such as increased body mass index, homeostasis model assessment of insulin resistance and high sensitive C-reactive protein levels) in the prediction of the inflammation in patients with polycystic ovary syndrome.
conclusionThe present study demonstrated that the monocyte count to high density lipoprotein cholesterol may be a novel and useful predictor of the presence of polycystic ovary syndrome.
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