Observational studyBMC pulmonary medicine2018
Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.
Observational study in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01748175 (Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma), which is not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.Human reproduction (Oxford, England) · 2022Pooled it
- Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.Annals of Saudi medicinePooled it
- Trial
- Remission in moderate-to-severe pediatric asthma: Definitions, assessment, prevalence, predictors, and outcomes-a scoping review.The journal of allergy and clinical immunology. Global · 2026Article
- Randomized study of the effects of testosterone administration on severity of asthma in horses.Journal of veterinary internal medicine · 2026Article
- High degree of remission in pediatric severe asthma patients treated with biologics in a real-world setting.The World Allergy Organization journal · 2026Article
- Article
- Metabolomic signatures of the steroid biosynthesis driving sex differences in clinical asthma subtypes.Research square · 2026Article
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026Review
- Quantifying the interaction between adiposity and hyperglycemia on incident asthma among youth.BMC public health · 2026Article
- Sex differences in immune cells: mechanistic perspectives and clinical correlates in physiology and disease.Frontiers in immunology · 2026Review
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Long-Term Pulmonary Function Outcomes in Children with Pulmonary Hypoplasia.The Journal of pediatrics · 2025Article
- The Relationship Between Contraceptive Use and Respiratory Function in Women: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Sex and Pubertal Status in Relation to Wheezing, Asthma, and Lung Function Development in a Multi-Ethnic Population-Based Prospective Cohort.Pediatric pulmonology · 2025Article
- Short-term exposure to relative humidity and lung health in early adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Research on the regulation of gut microbiota homeostasis and immune function in asthmatic mice by Huanglong Zhixiao Formula.Frontiers in microbiology · 2025Article
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundAlthough pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch.
methodsTo examine the effects of sex hormones on lung function and symptoms with puberty, Tanner stage was assessed in 187 children 6-18 years of age (59% severe) enrolled in the NIH/NHLBI Severe Asthma Research Program (SARP). The effects of circulating sex hormones (n = 68; testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, and progesterone) on lung function and 4 week symptom control (ACQ6) in cross-section were tested by linear regression.
resultsFrom pre-/early to late puberty, lung function did not change significantly but ACQ6 scores improved in males with severe asthma. By contrast females had lower post-BD FEV
conclusionsThese results support beneficial effects of androgens on lung function and symptom control and weak deleterious effects of estradiol on lung function in children with asthma. Longitudinal data are necessary to confirm these cross-sectional findings and to further elucidate hormonal mechanisms informing sex differences in asthma features with puberty.
trial registrationClinicalTrials.gov registration number: NCT01748175 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.