Evidence map›Paper›PMID 29631563›Full record

ArticleBMC psychiatry2018

Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study.

Md Rabiul Islam, Md Reazul Islam, M M A Shalahuddin Qusar, Mohammad Safiqul Islam, Md Humayun Kabir, G K M Mustafizur Rahman, Md Saiful Islam, Abul Hasnat

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07203144 (Selenium Supplementation for Improving Depression in Children and Adolescents), which is not on this map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07203144 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Selenium Supplementation for Improving Depression in Children and Adolescents: Efficacy and Mechanistic Study

TypeinterventionalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2025 to 2027Enrolled172ConditionsDepression - Major Depressive DisorderArmsselenium yeast supplementation, Placebo yeast supplementation
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Perturbations of Zinc Homeostasis and Onset of Neuropsychiatric Disorders.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Md Rabiul IslamDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh. robi.ayaan@gmail.com.
Md Reazul IslamDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
M M A Shalahuddin QusarDepartment of Psychiatry, Bangabandhu Sheikh Mujib Medical University, Dhaka, 1000, Bangladesh.
Mohammad Safiqul IslamDepartment of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
Md Humayun KabirDepartment of Soil Science, Faculty of Agriculture, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur, 1706, Bangladesh.
G K M Mustafizur RahmanDepartment of Soil Science, Faculty of Agriculture, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur, 1706, Bangladesh.
Md Saiful IslamDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
Abul HasnatDepartment of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
University of Dhaka · BDBangabandhu Sheikh Mujibur Rahman Agricultural University · BDBangabandhu Sheikh Mujib Medical University · BDNoakhali Science and Technology University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is a mixed disorder with the highly irregular course, inconsistent response to treatment and has no well-known mechanism for the pathophysiology. Major causes of depression are genetic, neurobiological, and environmental. However, over the past few years, altered serum levels of macro-minerals (MM) and trace elements (TE) have been recognized as major causative factors to the pathogenesis of many mental disorders. The purpose of this study was to determine the serum levels of MM (calcium and magnesium) and TE (copper, iron, manganese, selenium, and zinc) in MDD patients and find out their associations with depression risk.

methodsThis prospective case-control study recruited 247 patients and 248 healthy volunteers matched by age and sex. The serum levels of MM and TE were analyzed by atomic absorption spectroscopy (AAS). Statistical analysis was performed with independent sample t-tests and Pearson's correlation test.

resultsWe found significantly decreased concentrations of calcium and magnesium, iron, manganese, selenium, and zinc in MDD patients compared with control subjects (p < 0.05). But the concentration of copper was significantly increased in the patients than control subjects (p < 0.05). Data obtained from different inter-element relations in MDD patients and control subjects strongly suggest that there is a disturbance in the element homeostasis.

conclusionOur study suggests that altered serum concentrations of MM and TE are major contributing factors for the pathogenesis of MDD. Alterations of these elements in serum levels of MDD patients arise independently and they may provide a prognostic tool for the assessment of depression risk.

Indexed as

AdolescentAdultCase-Control StudiesFemaleHumansMajor Depressive DisorderMaleMiddle AgedMineralsProspective StudiesSpectrophotometry, AtomicTrace ElementsYoung AdultMineralsTrace ElementsCase-controlInter-element relationsMacro-mineralsMajor depressive disorderTrace elements

Identifiers

PMID29631563
PMCPMC5891975
OpenAlexW2803952783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.