Evidence map›Paper›PMID 29631414›Full record

ArticleAIDS research and human retroviruses2018

Comparative Assessment of Small and Large Intestine Biopsies for Ex Vivo HIV-1 Pathogenesis Studies.

Julie Elliott, Jennifer A Fulcher, F Javier Ibarrondo, Karen Tanner, Ian McGowan, Peter A Anton

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julie Elliott1 Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA , Los Angeles, California.
Jennifer A Fulcher2 Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA , Los Angeles, California.
F Javier Ibarrondo2 Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA , Los Angeles, California.
Karen Tanner1 Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA , Los Angeles, California.
Ian McGowan4 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Peter A Anton1 Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA , Los Angeles, California.
University of California, Los Angeles · USBlack AIDS Institute · USMagee-Womens Research Institute · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASAHARA, NORIYUKI · 1990 to 2019
$18.0M
The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 TransmissionK08AI124979 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FULCHER, JENNIFER · 2018 to 2021
$617k
NCATS NIH HHS KL2 TR001882NIAID NIH HHS K08 AI124979NIDDK NIH HHS P30 DK041301NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

Ex vivo mucosal explants have become a mainstay of HIV-1 studies using human tissue. In this study, we examine the baseline phenotypic and virologic differences between biopsies derived from the small intestine (SI) and large intestine (LI) for use in ex vivo explant studies. To do this, we collected endoscopic mucosal biopsies from both SI and LI from the same healthy, HIV-seronegative participants. Mucosal mononuclear cell phenotypes and quantity were compared using flow cytometry. Comparative HIV-1 infectibility of the explants was assessed using an ex vivo explant HIV-1 infection assay. We found that all biopsies had similar numbers of T cells per biopsy. While the percentage of CD4

Indexed as

BiopsyCD4-Positive T-LymphocytesHealthy VolunteersHIV-1HIV Core Protein p24HIV InfectionsHumansIntestinal MucosaIntestine, LargeIntestine, SmallLymphocyte ActivationModels, BiologicalPhenotypePrimary Cell CultureReceptors, HIVHIV Core Protein p24Receptors, HIVHIV-1 infectionintestinal mucosalarge intestinesmall intestine

Identifiers

PMID29631414
PMCPMC6204566
OpenAlexW2796692196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.