ArticleACS chemical biology2018
Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.
Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biosynthesis ofSynthetic and systems biotechnology · 2026Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Discovery of Uncommon Tryptophan-Containing Diketopiperazines fromJournal of natural products · 2024Article
- Terpenoid balance inScience advances · 2024Article
- Terpenoid balance inbioRxiv : the preprint server for biology · 2023Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- Diketomorpholines: Synthetic Accessibility and Utilization.ACS omega · 2022Review
- Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.Natural product reports · 2021Review
- Genome Mining and Molecular Networking-Based Metabolomics of the Marine FacultativeMolecules (Basel, Switzerland) · 2021Article
- Three diketomorpholines from a Penicillium sp. (strain G1071).Phytochemistry · 2021Article
- Article
- In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research.Fungal genetics and biology : FG & B · 2020Article
- Article
- Biosynthesis of Alkylcitric Acids inFrontiers in microbiology · 2020Article
- Bioprospecting Through Cloning of Whole Natural Product Biosynthetic Gene Clusters.Frontiers in bioengineering and biotechnology · 2020Review
- Tracing the mass flow from glucose and phenylalanine to pinoresinol and its glycosides in Phomopsis sp. XP-8 using stable isotope assisted TOF-MS.Scientific reports · 2019Article
- Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains.Angewandte Chemie (International ed. in English) · 2019Article
- Genetic platforms for heterologous expression of microbial natural products.Natural product reports · 2019Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Filamentous fungi are prolific producers of secondary metabolites with drug-like properties, and their genome sequences have revealed an untapped wealth of potential therapeutic leads. To better access these secondary metabolites and characterize their biosynthetic gene clusters, we applied a new platform for screening and heterologous expression of intact gene clusters that uses fungal artificial chromosomes and metabolomic scoring (FAC-MS). We leverage FAC-MS technology to identify the biosynthetic machinery responsible for production of acu-dioxomorpholine, a metabolite produced by the fungus, Aspergilllus aculeatus. The acu-dioxomorpholine nonribosomal peptide synthetase features a new type of condensation domain (designated C
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