ReviewBiomolecules & therapeutics2018
Effects and Mechanisms of Taurine as a Therapeutic Agent.
Review in Biomolecules & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05149716 (Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years), which is not on this map. Cited by 172 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years
Who cites it
172 citing papers in PubMed, 7 syntheses or guidelines pooled it, 382 citations in OpenAlex.
- Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms.Amino acids · 2026Pooled it
- Pooled it
- Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.Nutrition journal · 2024Pooled it
- Metabolism and gene sequence variation in Turicella otitidis implies its adaptability and pathogenicity in extra-otic infection: a systematic review.BMC infectious diseases · 2023Pooled it
- Pooled it
- Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.European journal of clinical nutrition · 2022Pooled it
- The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review.Frontiers in physiology · 2021Pooled it
- A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial.International journal of medical sciences · 2023Trial
- Urinary metabolomics data and cognitive performance in an adult population.Metabolic brain disease · 2026Article
- Formononetin Alleviates Cigarette Smoke Extract-Induced Lung Injury in Mice with Gut Microbiota and Taurine/SLC6A6/NF-κB Modulation.Molecules (Basel, Switzerland) · 2026Article
- Taurine supplementation in fish meal-free diet improved growth, alleviated hypoxic-induced gill injury associating with CaAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Dietary taurine-mediated alleviation of post-hatch transport stress in broilers: Improvements in growth, antioxidant status, and intestinal barrier integrity linked to gut microbiota modulation.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Enzalutamide-Induced Host Metabolic Reprogramming Is Associated with Treatment Outcomes in Patients with Castration-Resistant Prostate Cancer: A Hypothesis-Generating Study.Clinical pharmacology and therapeutics · 2026Article
- Effects of Different Types of Pectin Oligosaccharides on the Community Structure and Metabolism of Human Fecal Microbiota.Microorganisms · 2026Article
- Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study.European journal of nutrition · 2026Observational
- Effects of combined low-dose caffeine and taurine on anaerobic, neuromuscular, and cognitive performance: a double-blind randomized placebo-controlled crossover study.BMC sports science, medicine & rehabilitation · 2026Article
- Fatigue-associated gut bacteria in Japanese healthy adults characterized by metagenomic analysis.Scientific reports · 2026Article
- Dietary Taurine Enhances Intestinal Digestion, Absorption, and Villus Morphology in Mice.Animals : an open access journal from MDPI · 2026Article
- Review
- The role of taurine in modulating metal accumulation and gene expression under cadmium stress in Glycyrrhiza glabra.BMC plant biology · 2026Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking taurine show major pathology. These findings have spurred interest in the potential use of taurine as a therapeutic agent. The discovery that taurine is an effective therapy against congestive heart failure led to the study of taurine as a therapeutic agent against other disease conditions. Today, taurine has been approved for the treatment of congestive heart failure in Japan and shows promise in the treatment of several other diseases. The present review summarizes studies supporting a role of taurine in the treatment of diseases of muscle, the central nervous system, and the cardiovascular system. In addition, taurine is extremely effective in the treatment of the mitochondrial disease, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and offers a new approach for the treatment of metabolic diseases, such as diabetes, and inflammatory diseases, such as arthritis. The review also addresses the functions of taurine (regulation of antioxidation, energy metabolism, gene expression, ER stress, neuromodulation, quality control and calcium homeostasis) underlying these therapeutic actions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.