SynthesisJournal of psychiatric research2018
Posttraumatic stress disorder and nonadherence to medications prescribed for chronic medical conditions: A meta-analysis.
Synthesis in Journal of psychiatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence and incidence of post-traumatic stress disorder and symptoms in people with chronic somatic diseases: A systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Early interventions to prevent posttraumatic stress disorder symptoms in survivors of life-threatening medical events: A systematic review.Journal of anxiety disorders · 2019Pooled it
- A remote intervention to improve medication nonadherence guided by a marker of risk derived from the electronic health records of adolescent transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Trial
- Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Trial
- Lifetime congenital urologic care: centering patient voices.Journal of patient-reported outcomes · 2026Article
- Associations of fear of recurrence and social support with post-traumatic stress disorder and disease recurrence in patients with severe acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Understanding and supporting parenting in parents seeking PTSD treatment: a qualitative study.European journal of psychotraumatology · 2025Article
- Article
- Prevalence and associated factors of depression and posttraumatic stress disorder among trauma patients: multi-centered cross-sectional study.Frontiers in psychiatry · 2025Article
- Clinical Education: Addressing Prior Trauma and Its Impacts in Medical Settings.Journal of clinical psychology in medical settings · 2024Review
- Psychophysiological effects of equine-facilitated psychotherapy on Veterans with PTSD and their horse partners.Journal of military, veteran and family health · 2024Article
- Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans.Journal of the American Heart Association · 2024Article
- The association of post-traumatic stress disorder with glomerular filtration rate decline.Nephrology (Carlton, Vic.) · 2023Article
- Study protocol: development and randomized controlled trial of a preventive blended care parenting intervention for parents with PTSD.BMC psychiatry · 2023Article
- Trauma-informed patient and public-engaged research: Development and evaluation of an online training programme.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Posttraumatic stress disorder and diabetes-related outcomes in patients with type 1 diabetes.Scientific reports · 2023Article
- Optimization of Therapy in Patients with Epilepsy and Psychiatric Comorbidities: Key Points.Current neuropharmacology · 2023Article
- Posttraumatic Stress Disorder (PTSD) as a Risk Factor for Cardiovascular Disease: Implications for Future Research and Clinical Care.Current cardiology reports · 2022Review
- Intimate Relationships and Coronary Heart Disease: Implications for Risk, Prevention, and Patient Management.Current cardiology reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with posttraumatic stress disorder (PTSD) are at increased risk for adverse consequences from comorbid medical conditions. Nonadherence to medications prescribed to treat those comorbid conditions may help explain this increased risk. We sought to determine the association between PTSD and medication nonadherence and whether it varied according to the type of event inducing the PTSD.
methodsProspective observational cohort or cross-sectional studies relating PTSD and nonadherence among adults prescribed medications for a chronic medical illness were identified by searching MEDLINE, EMBASE, PsycINFO, the Cochrane Library, CINAHL, SCOPUS, and the PILOTS Database and by hand-searching bibliographies from selected articles. Individual estimates of odds ratios were pooled using random effects meta-analysis with inverse variance weighting. Articles were pooled separately according to whether PTSD was induced by a medical versus non-medical event. OUTCOMES: Sixteen articles comprising 4483 patients met eligibility criteria. The pooled effect size of the risk of PTSD to medication nonadherence was OR 1.22 (95% CI, 1.06-1.41). Among the 6 studies of medical event-induced PTSD, the OR was 2.08 (95% CI, 1.03-4.18); p = 0.04. Among the 8 studies in which PTSD was not induced by a medical event, the OR was 1.10 (95% CI, 0.99-1.24); p = 0.09.
interpretationPatients with PTSD were more likely to be nonadherent to medications prescribed for chronic medical conditions - an association that may exist specifically when PTSD was induced by a medical event. Medications may serve as aversive reminders among survivors of acute medical events, magnifying avoidance behaviors characteristic of PTSD.
fundingNHLBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.