Evidence map›Paper›PMID 29631121›Full record

ReviewCurrent opinion in chemical biology2018

Molecular imaging agents for ultrasound.

Aimen Zlitni, Sanjiv S Gambhir

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  3. Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aimen ZlitniDepartment of Radiology, Molecular Imaging Program at Stanford, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, United States.
Sanjiv S GambhirDepartment of Radiology, Molecular Imaging Program at Stanford, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, United States; Department of Bioengineering, Department of Materials Science and Engineering, Stanford University, Stanford, CA, United States. Electronic address: sgambhir@stanford.edu.
Stanford University · US

Funding

Stanford Nanocharacterization LaboratoryU54CA119367 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2006 to 2010
$19.8M
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Reporter Imaging of Protein-Protein InteractionsR01CA082214 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GAMBHIR, SANJIV S · 1999 to 2019
$5.9M
New Tools for Prostate Cancer Detection and PrognosticationU01CA152737 · NCI · STANFORD UNIVERSITY · PI BROOKS, JAMES D., GAMBHIR, SANJIV S · 2010 to 2015
$2.8M
Imaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter PrR01CA135486 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2008 to 2012
$1.3M
Improved Prostate Cancer Detection Using Combined Ultrasound and Photoacoustic ImR21CA178360 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2013 to 2014
$369k
NCI NIH HHS P50 CA114747NCI NIH HHS R01 CA082214NCI NIH HHS R01 CA135486NCI NIH HHS R21 CA178360NCI NIH HHS U01 CA152737NCI NIH HHS U54 CA119367NCI NIH HHS U54 CA151459NCI NIH HHS U54 CA199075
6 · The paper itself

Abstract

Ultrasound (US) imaging is a safe, sensitive and affordable imaging modality with a wide usage in the clinic. US signal can be further enhanced by using echogenic contrast agents (UCAs) which amplify the US signal. Developments in UCAs which are targeted to sites of disease allow the use of US imaging to provide molecular information. Unfortunately, traditional UCAs are too large to leave the vascular space limiting the application of molecular US to intravascular markers. In this mini review, we highlight the most recent reports on the application of molecular US imaging in the clinic and summarize the latest nanoparticle platforms used to develop nUCAs. We believe that the highlighted technologies will have a great impact on the evolution of the US imaging field.

Indexed as

AnimalsContrast MediaHumansMicrobubblesMolecular ImagingNanoparticlesNanotechnologyUltrasonographyContrast Media

Identifiers

PMID29631121
PMCPMC6609297
OpenAlexW2795483813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.