Evidence map›Paper›PMID 29631023›Full record

ReviewProgress in neurobiology2018

Regulation and function of neurogenesis in the adult mammalian hypothalamus.

Sooyeon Yoo, Seth Blackshaw

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. The role of tanycytes in the regulation of energy balance.Reviews in endocrine & metabolic disorders · 2026
    Review
  6. Changes in the brain [NADFrontiers in aging neuroscience · 2026
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sooyeon YooSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Center for Human Systems Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: sblack@jhmi.edu.

Funding

The Function and Regulation of Tanycyte-Derived Hypothalamic NeurogenesisR01DK108230 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2016 to 2019
$1.5M
NIDDK NIH HHS R01 DK108230
6 · The paper itself

Abstract

Over the past two decades, evidence has accumulated that neurogenesis can occur in both the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can be regulated by dietary, environmental and hormonal signals. Since the hypothalamus has a central role in controlling a broad range of homeostatic physiological processes, these findings may have far ranging behavioral and medical implications. However, many questions in the field remain unresolved, including the cells of origin of newborn hypothalamic neurons and the extent to which these cells actually regulate hypothalamic-controlled behaviors. In this manuscript, we conduct a critical review of the literature on postnatal hypothalamic neurogenesis in mammals, lay out the main outstanding controversies in the field, and discuss how best to advance our knowledge of this fascinating but still poorly understood process.

Indexed as

AnimalsHumansHypothalamusNeurogenesisAgingCeproductionHypothalamusMüller gliaNeurogenesisObesityPlasticityProgenitorSexual dimorphismStem cellTanycytes

Identifiers

PMID29631023
PMCPMC6173995

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.