ArticleJournal of immunological methods2018
Inducible disruption of the c-myb gene allows allogeneic bone marrow transplantation without irradiation.
Article in Journal of immunological methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia.eLife · 2024Article
- Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation.Nature communications · 2020Article
- The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties.Journal of the American Society of Nephrology : JASN · 2020Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Allogeneic bone marrow (BM) transplantation enables the in vivo functional assessment of hematopoietic cells. As pre-conditioning, ionizing radiation is commonly applied to induce BM depletion, however, it exerts adverse effects on the animal and can limit experimental outcome. Here, we provide an alternative method that harnesses conditional gene deletion to ablate c-myb and thereby deplete BM cells, hence allowing BM substitution without other pre-conditioning. The protocol results in a high level of blood chimerism after allogeneic BM transplantation, whereas immune cells in peripheral tissues such as resident macrophages are not replaced. Further, mice featuring a low chimerism after initial transplantation can undergo a second induction cycle for efficient deletion of residual BM cells without the necessity to re-apply donor cells. In summary, we present an effective c-myb-dependent genetic technique to generate BM chimeras in the absence of irradiation or other methods for pre-conditioning.
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Registered trials
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