Evidence map›Paper›PMID 29630955›Full record

ArticleUrology2018

Multi-institutional Evaluation of Upper Urinary Tract Biopsy Using Backloaded Cup Biopsy Forceps, a Nitinol Basket, and Standard Cup Biopsy Forceps.

Daniel J Lama, Shoaib Safiullah, Roshan M Patel, Thomas K Lee, Jyoti P Balani, Lishi Zhang, Zhamshid Okhunov, Vitaly Margulis, Stephen J Savage, Edward Uchio and 1 more

Abstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  9. Biological and prognostic implications of biopsy upgrading for high-grade upper tract urothelial carcinoma at nephroureterectomy.International journal of urology : official journal of the Japanese Urological Association · 2023
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  19. A novel upper tract ureteroscopic biopsy technique: the "form tackle".International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daniel J LamaDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA. Electronic address: DLamajr@gmail.com.
Shoaib SafiullahDivision of Urology, Department of Surgery, University of Missouri (MU), Columbia, MO.
Roshan M PatelDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA.
Thomas K LeeDepartment of Pathology, University of California, Irvine (UCI) Medical Center, Orange, CA.
Jyoti P BalaniDepartment of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX.
Lishi ZhangDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA.
Zhamshid OkhunovDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA.
Vitaly MargulisDepartment of Urology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX.
Stephen J SavageDepartment of Urology, Medical University of South Carolina (MUSC), Charleston, SC.
Edward UchioDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA.
Jaime LandmanDepartment of Urology, University of California, Irvine (UCI) Medical Center, Orange, CA.
University of California, Irvine Medical Center · USMedical University of South Carolina · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of Missouri · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

objectiveTo compare the performance of 3 contemporary ureteroscopic biopsy devices for the histopathologic diagnosis of upper tract urothelial carcinoma (UTUC).

methodsWe retrospectively reviewed 145 patients who underwent 182 urothelial biopsies using 2.4F backloaded cup biopsy forceps, a nitinol basket, or 3F standard cup biopsy forceps at 3 tertiary academic centers between 2011 and 2016. Experienced genitourinary pathologists provided an assessment of each specimen without knowledge of the device used for biopsy. For patients who underwent nephroureterectomy without neoadjuvant chemotherapy within 3 months of biopsy-proven UTUC diagnosis, the biopsy grade was compared with both the grade and stage of the surgical specimen.

resultsBiopsy utilization varied among the 3 institutions (P <.0001). Significant variabilities in specimen size (P = .001), the presence of intact urothelium (P = .008), and crush artifact (P = .028) were found among the biopsy devices. The quality of specimens from backloaded cup forceps was rated similarly to the nitinol basket (P >.05) and was favored over standard cup forceps specimens. Grade concordance was not affected by specimen size (P >.05), morphology (P >.1), or location (P >.5). No difference existed among the devices in the rate of acquiring a grade concordant biopsy; however, the backloaded cup forceps provided concordant biopsies that could be distinguished as low- and high-grade (P = .02).

conclusionThe backloaded cup forceps and nitinol basket obtained a higher quality urothelial specimen compared with standard cup forceps. Ureteroscopic biopsy device selection did not significantly impact the accuracy of the histologic diagnosis of UTUC.

Indexed as

AgedAged, 80 and overAlloysBiopsyCarcinoma, Transitional CellFemaleHumansKidney NeoplasmsMaleMiddle AgedNeoplasm GradingNeoplasm StagingNephroureterectomyRetrospective StudiesSurgical InstrumentsUreteral NeoplasmsAlloysnitinol

Identifiers

PMID29630955
PMCPMC6214198
OpenAlexW2795847443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.