Evidence map›Paper›PMID 29630654›Full record

ArticlePloS one2018

"We did not know what was wrong"-Barriers along the care cascade among hospitalized adolescents with HIV in Gaborone, Botswana.

Leslie A Enane, Keboletse Mokete, Dipesalema Joel, Rahul Daimari, Ontibile Tshume, Gabriel Anabwani, Loeto Mazhani, Andrew P Steenhoff, Elizabeth D Lowenthal

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Leslie A EnaneDivision of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0001-8390-5881
Keboletse MoketeBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Dipesalema JoelBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Rahul DaimariFaculty of Medicine, University of Botswana, Gaborone, Botswana.
Ontibile TshumeBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Gabriel AnabwaniBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Loeto MazhaniFaculty of Medicine, University of Botswana, Gaborone, Botswana.
Andrew P SteenhoffDivision of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Elizabeth D LowenthalDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Children's Hospital of Philadelphia · USUniversity of Botswana · BWBotswana-Baylor Children's Clinical Center of Excellence · BWBaylor College of Medicine · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Targeted Monitoring and Determinants of Adherence in Adolescents with HIVK23MH095669 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN · 2012 to 2016
$874k
NIAID NIH HHS P30 AI045008NIH HHS K23 MH095669NIH HHS P30 AI045008NIMH NIH HHS K23 MH095669
6 · The paper itself

Abstract

High mortality among adolescents with HIV reflects delays and failures in the care cascade. We sought to elucidate critical missed opportunities and barriers to care among adolescents hospitalized with HIV at Botswana's tertiary referral hospital. We enrolled all HIV-infected adolescents (aged 10-19 years) hospitalized with any diagnosis other than pregnancy from July 2015 to January 2016. Medical records were reviewed for clinical variables and past engagement in care. Semi-structured interviews of the adolescents (when feasible) and their caregivers explored delays and barriers to care. Twenty-one eligible adolescents were identified and 15 were enrolled. All but one were WHO Clinical Stage 3 or 4. Barriers to diagnosis included lack of awareness about perinatal HIV infection, illness or death of the mother, and fear of discrimination. Barriers to adherence to antiretroviral therapy included nondisclosure, isolation, and mental health concerns. The number of hospitalized HIV-infected adolescents was lower than expected. However, among those hospitalized, the lack of timely diagnosis and subsequent gaps in the care cascade elucidated opportunities to improve outcomes and quality of life for this vulnerable group.

Indexed as

Delayed DiagnosisAdolescentAnti-HIV AgentsBotswanaChildFemaleHealth Services AccessibilityHIV InfectionsHospitalizationHumansInfectious Disease Transmission, VerticalMaleMedication AdherencePregnancyYoung AdultAnti-HIV Agents

Identifiers

PMID29630654
PMCPMC5890999
OpenAlexW2797132531

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.