ArticlePloS one2018
The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pregnancy outcomes in freeze-all versus fresh embryo transfer cycles of women with adenomyosis and endometriosis: a systemic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Impact of prolonged embryo storage on reproductive and neonatal outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Association of embryo transfer type with infertility in endometriosis: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2022Pooled it
- Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?BMC pregnancy and childbirth · 2020Pooled it
- Endometriosis and ART: A prior history of surgery for OMA is associated with a poor ovarian response to hyperstimulation.PloS one · 2018Trial
- Diagnosis and Management of Chronic Endometritis: Effects on Postoperative Pregnancy Outcomes in Endometriosis Patients with Proximal Tubal Obstruction Undergoing Hysteroscopic Tubal Catheterization and Laparoscopy.Journal of clinical medicine · 2026Article
- Serum progesterone concentrations at frozen embryo transfer in women with adenomyosis and endometriosis: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Endometriosis and In Vitro Fertilization.Medicina (Kaunas, Lithuania) · 2024Review
- The Current Understanding of Molecular Mechanisms in Adenomyosis-Associated Infertility and the Treatment Strategy for Assisted Reproductive Technology.International journal of molecular sciences · 2024Review
- Fresh or frozen day 6 blastocyst transfer: is there still a question?Reproductive biology and endocrinology : RB&E · 2024Article
- Critical appraisal and narrative review of the literature in IVF/ICSI patients with adenomyosis and endometriosis.Frontiers in reproductive health · 2024Article
- IVF/ICSI Outcomes After a Freeze-All Strategy: an Observational Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2023Observational
- Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications.Journal of personalized medicine · 2023Review
- Impact of adenomyosis and endometriosis on IVF/ICSI pregnancy outcome in patients undergoing gonadotropin-releasing hormone agonist treatment and frozen embryo transfer.Scientific reports · 2023Article
- Supplementary dydrogesterone is beneficial as luteal phase support in artificial frozen-thawed embryo transfer cycles compared to micronized progesterone alone.Frontiers in endocrinology · 2023Article
- Implantation Failure in Endometriosis Patients: Etiopathogenesis.Journal of clinical medicine · 2022Review
- ART Outcomes After Hysteroscopic Proximal Tubal Occlusion Versus Laparoscopic Salpingectomy for Hydrosalpinx Management in Endometriosis Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2022Observational
- Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre.BMC research notes · 2021Article
- Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControlled ovarian stimulation in assisted reproduction technology (ART) may alters endometrial receptivity by an advancement of endometrial development. Recently, technical improvements in vitrification make deferred frozen-thawed embryo transfer (Def-ET) a feasible alternative to fresh embryo transfer (ET). In endometriosis-related infertility the eutopic endometrium is abnormal and its functional alterations are seen as likely to alter the quality of endometrial receptivity. One question in the endometriosis ART-management is to know whether Def-ET could restore optimal receptivity in endometriosis-affected women leading to increase in pregnancy rates.
objectiveTo compare cumulative ART-outcomes between fresh versus Def-ET in endometriosis-infertile women. MATERIALS AND
methodsThis matched cohort study compared def-ET strategy to fresh ET strategy between 01/10/2012 and 31/12/2014. One hundred and thirty-five endometriosis-affected women with a scheduled def-ET cycle and 424 endometriosis-affected women with a scheduled fresh ET cycle were eligible for matching. Matching criteria were: age, number of prior ART cycles, and endometriosis phenotype. Statistical analyses were conducted using univariable and multivariable logistic regression models.
results135 in the fresh ET group and 135 in the def-ET group were included in the analysis. The cumulative clinical pregnancy rate was significantly increased in the def-ET group compared to the fresh ET group [58 (43%) vs. 40 (29.6%), p = 0.047]. The cumulative ongoing pregnancy rate was 34.8% (n = 47) and 17.8% (n = 24) respectively in the Def-ET and the fresh-ET groups (p = 0.005). After multivariable conditional logistic regression analysis, Def-ET was associated with a significant increase in the cumulative ongoing pregnancy rate as compared to fresh ET (OR = 1.76, CI95% 1.06-2.92, p = 0.028).
conclusionDef-ET in endometriosis-affected women was associated with significantly higher cumulative ongoing pregnancy rates. Our preliminary results suggest that Def-ET for endometriosis-affected women is an attractive option that could increase their ART success rates. Future studies, with a randomized design, should be conducted to further confirm those results.
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