SynthesisObstetrics and gynecology2018
Opioid Detoxification During Pregnancy: A Systematic Review.
Synthesis in Obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 110 citations in OpenAlex.
- Outcomes in offspring of interventions to treat substance use in pregnancy: protocol for an umbrella review.Systematic reviews · 2026Article
- Logistic and patient preference-driven therapeutic stance in an opioid-dependent pregnant female: A case report.Indian journal of psychiatry · 2026Article
- Associations between maternal opioid use disorder treatment and pregnancy outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Bringing MOUD "In House": Implementing an Internal MOUD Program During Pregnancy in a State Prison.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2026Article
- Hospital Care for Pregnant Persons With OUD Review.American journal of medicine open · 2025Review
- Prenatal drug use criminalization and health system avoidance: Evidence from births in Alabama, South Carolina, and Tennessee, 1989-2019.Social science & medicine (1982) · 2025Article
- Cost-Effectiveness of Treatment for Opioid Use Disorder in Pregnancy and Its Impact on Birth Outcomes.JAMA pediatrics · 2025Article
- Association between buprenorphine dose and outcomes among pregnant persons with opioid use disorder.American journal of obstetrics and gynecology · 2025Article
- National consensus statement on opioid agonist treatment in custodial settings.The Medical journal of Australia · 2025Article
- The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research.CNS drugs · 2025Article
- "They talked to me like I was dirt under their feet:" Treatment and withdrawal experiences of incarcerated pregnant people with opioid use disorder in four U.S. states.SSM. Qualitative research in health · 2024Article
- Opioid Medical Detoxification Compared to Opioid Agonist Treatment during Pregnancy: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Low-dose buprenorphine initiation during pregnancy: a case report.AJOG global reports · 2024Article
- Antenatal care of women who use opioids: a qualitative study of practitioners' perceptions of strengths and challenges of current service provision in Scotland.BMC pregnancy and childbirth · 2024Article
- The Psychiatrist's Role in Treating Perinatal Opioid Use Disorder and Reducing Maternal Mortality.Focus (American Psychiatric Publishing) · 2024Review
- Racial and Ethnic Inequities in Buprenorphine and Methadone Utilization Among Reproductive-Age Women with Opioid Use Disorder: an Analysis of Multi-state Medicaid Claims in the USA.Journal of general internal medicine · 2023Article
- Assessing provision of MOUD and obstetric care in U.S. jails: A content analysis of policies submitted by 59 jails.Drug and alcohol dependence · 2023Article
- Interventions to Support Engagement in Addiction Care Postpartum: Principles and Pitfalls.Substance abuse and rehabilitation · 2023Review
- State Laws on Substance Use Treatment for Incarcerated Pregnant and Postpartum People.Substance abuse : research and treatment · 2023Article
- Principles of care for pregnant and parenting people with substance use disorder: the obstetrician gynecologist perspective.Frontiers in pediatrics · 2023Review
Corrections and comments
- Commented on by
- Commented on byIn Reply.2018
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo systematically review maternal and neonatal outcomes associated with opioid detoxification during pregnancy. DATA SOURCES: PubMed, PsycINFO, EMBASE, Cochrane, and ClinicalTrials.gov databases were searched from January 1, 1966, to September 1, 2016. METHODS OF STUDY SELECTION: English-language studies that reported outcomes associated with opioid detoxification among pregnant women with opioid use disorder were included. Nonoriginal research articles (case reports, editorials, reviews) and studies that failed to report outcomes for detoxification participants were excluded. Bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias and quality was assessed using the U.S. Preventive Service Task Force Quality of Evidence scale. TABULATION, INTEGRATION, AND
resultsOf 1,315 unique abstracts identified, 15 met criteria for inclusion and included 1,997 participants, of whom 1,126 underwent detoxification. Study quality ranged from fair to poor as a result of the lack of a randomized control or comparison arm and high risk of bias across all studies. Only nine studies had a comparison arm. Detoxification completion (9-100%) and illicit drug relapse (0-100%) rates varied widely across studies depending on whether data from participants who did not complete detoxification or who were lost to follow-up were included in analyses. The reported rate of fetal loss was similar among women who did (14 [1.2%]) and did not undergo detoxification (17 [2.0%]).
conclusionsEvidence does not support detoxification as a recommended treatment intervention as a result of low detoxification completion rates, high rates of relapse, and limited data regarding the effect of detoxification on maternal and neonatal outcomes beyond delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.