ArticleJournal of clinical neurology (Seoul, Korea)2018
Role of Language-Related Functional Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.
Article in Journal of clinical neurology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Language Dysfunction Associated with Pathological Brain Connectivity in Children with Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS.Annals of clinical and translational neurology · 2026Article
- Linking Cortical Morphometry in Self-Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture.CNS neuroscience & therapeutics · 2026Article
- Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.European radiology · 2025Article
- Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.Life (Basel, Switzerland) · 2023Article
- Disrupted functional connectivity patterns of the left inferior frontal gyrus subregions in benign childhood epilepsy with centrotemporal spikes.Translational pediatrics · 2022Article
- Cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes and attention deficit hyperactivity disorder: a prospective study.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Connectome-based prediction of brain age in Rolandic epilepsy: a protocol for a multicenter cross-sectional study.Annals of translational medicine · 2021Article
- Artificial Intelligence and Computational Approaches for Epilepsy.Journal of epilepsy research · 2020Review
- [Research advances in multimodal magnetic resonance for cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Variation of functional brain connectivity in epileptic seizures: an EEG analysis with cross-frequency phase synchronization.Cognitive neurodynamics · 2020Article
- The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies.Epilepsia · 2019Review
- Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes.Frontiers in neurology · 2019Article
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7 authors.
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Abstract
background and purposeBenign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between cognitive performance and altered functional connectivity (FC) in the resting-state brain networks of BECTS patients.
methodsWe studied 42 subjects, comprising 19 BECTS patients and 23 healthy controls. Cognitive performance was assessed using the Korean version of the Wechsler Intelligence Scale for Children-III, in addition to verbal and visuospatial memory tests and executive function tests. Resting-state functional magnetic resonance imaging was acquired in addition to high-resolution structural data. We selected Rolandic and language-related areas as regions of interest (ROIs) and analyzed the seed-based FC to voxels throughout the brain. We evaluated the correlations between the neuropsychological test scores and seed-based FC values using the same ROIs.
resultsThe verbal intelligence quotient (VIQ) and full-scale intelligence quotient (FSIQ) were lower in BECTS patients than in healthy controls (p<0.001). The prevalence of subjects with a higher performance IQ than VIQ was significantly higher in BECTS patients than in healthy controls (73.7% vs. 26.1%, respectively; p=0.002). Both the Rolandic and language-related ROIs exhibited more enhanced FC to voxels in the left inferior temporal gyrus in BECTS patients than in healthy controls. A particularly interestingly finding was that the enhanced FC was correlated with lower cognitive performance as measured by the VIQ and the FSIQ in both patients and control subjects.
conclusionsOur findings suggest that the FC alterations in resting-state brain networks related to the seizure onset zone and language processing areas could be related to adaptive plasticity for coping with cognitive dysfunction.
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