ArticleJournal of clinical neurology (Seoul, Korea)2018
Changes in the Common Carotid Artery after Radiotherapy: Wall Thickness, Calcification, and Atherosclerosis.
Article in Journal of clinical neurology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Diagnostic Performance of Duplex Ultrasonography in Post-Radiation Common Carotid Artery Stenosis: A Cross-Sectional Validation Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Radiation-Induced Carotid Artery Disease: Pathogenesis, Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- Stomal Bleeding in a Laryngectomized Patient as a Consequence of an Infected Innominate Artery Stent: A Case Report.Head & neck · 2025Article
- Carotid artery stenosis and ischemic cerebrovascular events after radiotherapy in patients with head and neck cancer.PloS one · 2025Article
- The imaging presentation of head and neck oncologic emergencies.Journal of clinical imaging science · 2025Article
- Association between modifiable vascular risk factors and rapid progression of postradiation carotid artery stenosis.Journal of the Chinese Medical Association : JCMA · 2023Article
- When Two Maladies Meet: Disease Burden and Pathophysiology of Stroke in Cancer.International journal of molecular sciences · 2022Review
- Cardiovascular Manifestations From Therapeutic Radiation: A Multidisciplinary Expert Consensus Statement From the International Cardio-Oncology Society.JACC. CardioOncology · 2021Review
- Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors.Frontiers in pharmacology · 2021Article
- Early-Stage Glottic Squamous Cell Carcinoma in the Era of Image-Guided Radiotherapy.Frontiers in oncology · 2021Review
- Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma.Radiation oncology (London, England) · 2020Article
- Management of Radiation Induced Carotid Stenosis in Head and Neck Cancer.Translational oncology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSince the long-term survival rate has improved in laryngeal cancer patients who receive radiotherapy, concerns about postradiation complications (including carotid atherosclerosis) have increased. We followed changes in the common carotid artery (CCA) after radiotherapy and identified the underlying risk factors.
methodsConsecutive patients with laryngeal cancer who underwent radiotherapy between January 1999 and December 2009 and who had received computed tomography (CT) both pre- and postradiotherapy were enrolled. Changes in the wall thickness and in the vessel and lumen areas as well as the presence of calcification or atherosclerosis were investigated. Demographics and risk factors were compared between patients with and without atherosclerosis at follow-up CT.
resultsIn total, 125 patients were enrolled. The wall thickness had increased and the lumen area had decreased several months after radiotherapy. These changes were not associated with vascular risk factors and were not progressive. Calcification and atherosclerosis were observed in 37 (29.6%) and 71 (56.8%) patients, respectively. Diabetes was associated with calcification (p=0.02). The prevalence of hyperlipidemia was higher in patients with atherosclerosis (28.2% vs. 11.1%, p=0.02) and for a longer period postradiation [62.7±32.1 vs. 40.0±24.2 months (mean±SD), p<0.001]. Atherosclerosis occurred mostly in the middle portion of the CCA (n=31, 24.6%), followed by the proximal CCA at the intrathoracic level (n=26, 20.6%) and the distal CCA (n=6, 4.8%). Positive remodeling was also observed, but this was less common in patients with calcification (p=0.02).
conclusionsVarious types of postradiation changes occur in the CCA and can be easily observed in postradiation CT. The prevalence and burden of postradiation atherosclerosis increased in a close relationship with baseline cholesterol levels and the time after radiotherapy. Postradiation atherosclerosis was observed at unusual sites of the CCA.
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