ArticleBrain imaging and behavior2019
Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06713070 (Pattern of Gait Abnormality As a Predictor for Disease Progression in Dementia), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pattern of Gait Abnormality As a Predictor for Disease Progression in Dementia
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The effect of cognitive rehabilitation on motor function and balance in individuals with multiple sclerosis: a systematic review.Acta neurologica Belgica · 2025Pooled it
- Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.Gerontology · 2024Pooled it
- Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults.JAMA network open · 2022Trial
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Gait Variability Is Associated With Gray Matter Volumes Implicated in Cognitive Function: A Cross-Sectional Analysis From the AGUEDA Trial.Innovation in aging · 2025Article
- Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.Neurobiology of aging · 2024Article
- Longitudinal Associations of Social Support and Gait Speed Decline in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Effect of the Human Brainstem Myelination on Gait Speed in Normative Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Development of a Gait Feature-Based Model for Classifying Cognitive Disorders Using a Single Wearable Inertial Sensor.Neurology · 2023Article
- Neural signature of mobility-related everyday function in older adults at-risk of cognitive impairment.Neurobiology of aging · 2023Article
- Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults.Frontiers in aging neuroscience · 2023Article
- Visual-somatosensory integration (VSI) as a novel marker of Alzheimer's disease: A comprehensive overview of the VSI study.Frontiers in aging neuroscience · 2023Article
- Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Gait-Related Metabolic Covariance Networks at Rest in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Relative Trajectories of Gait and Cognitive Decline in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Brain patterns of pace - but not rhythm - are associated with vascular disease in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?Frontiers in aging neuroscience · 2022Article
- Cognitive Dysfunction and Gait Abnormalities in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2021Article
- Dual-task performance is associated with brain MRI Morphometry in individuals with mild cognitive impairment.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 5 countries.
Funding
Abstract
Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.